EEG recording latency in critically ill patients: Impact on outcome. An analysis of a randomized controlled trial (CERTA)
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EEG recording latency in critically ill patients : Impact on outcome. An analysis of a randomized controlled trial (CERTA). / Urbano, Valentina; Novy, Jan; Alvarez, Vincent; Schindler, Kaspar; Rüegg, Stephan; Rossetti, Andrea O.
In: Clinical Neurophysiology, Vol. 139, 2022, p. 23-27.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - EEG recording latency in critically ill patients
T2 - Impact on outcome. An analysis of a randomized controlled trial (CERTA)
AU - Urbano, Valentina
AU - Novy, Jan
AU - Alvarez, Vincent
AU - Schindler, Kaspar
AU - Rüegg, Stephan
AU - Rossetti, Andrea O.
N1 - Publisher Copyright: © 2022 International Federation of Clinical Neurophysiology
PY - 2022
Y1 - 2022
N2 - Objective: To assess, in adults with acute consciousness impairment, the impact of latency between hospital admission and EEG recording start, and their outcome. Methods: We reviewed data of the CERTA trial (NCT03129438) and explored correlations between EEG recording latency and mortality, Cerebral Performance Categories (CPC), and modified Rankin Scale (mRS) at 6 months, considering other variables, using uni- and multivariable analyses. Results: In univariable analysis of 364 adults, median latency between admission and EEG recordings was comparable between surviving (61.1 h; IQR: 24.3–137.7) and deceased patients (57.5 h; IQR: 22.3–141.1); p = 0.727. This did not change after adjusting for potential confounders, such as lower Glasgow Coma Score on enrolment (p < 0.001) and seizure or status epilepticus detection (p < 0.001). There was neither any correlation between EEG latency and mRS (rho 0.087, p 0.236), nor with CPC (rho = 0.027, p = 0.603). Conclusion: This analysis shows no correlation between delays of EEG recordings and mortality or functional outcomes at 6 months in critically ill adults. Significance: These findings might suggest that in critically ill adults mortality correlates with underlying brain injury rather than EEG delay.
AB - Objective: To assess, in adults with acute consciousness impairment, the impact of latency between hospital admission and EEG recording start, and their outcome. Methods: We reviewed data of the CERTA trial (NCT03129438) and explored correlations between EEG recording latency and mortality, Cerebral Performance Categories (CPC), and modified Rankin Scale (mRS) at 6 months, considering other variables, using uni- and multivariable analyses. Results: In univariable analysis of 364 adults, median latency between admission and EEG recordings was comparable between surviving (61.1 h; IQR: 24.3–137.7) and deceased patients (57.5 h; IQR: 22.3–141.1); p = 0.727. This did not change after adjusting for potential confounders, such as lower Glasgow Coma Score on enrolment (p < 0.001) and seizure or status epilepticus detection (p < 0.001). There was neither any correlation between EEG latency and mRS (rho 0.087, p 0.236), nor with CPC (rho = 0.027, p = 0.603). Conclusion: This analysis shows no correlation between delays of EEG recordings and mortality or functional outcomes at 6 months in critically ill adults. Significance: These findings might suggest that in critically ill adults mortality correlates with underlying brain injury rather than EEG delay.
KW - Electroencephalography
KW - Intensive care unit
KW - Prognosis
KW - Seizures
KW - Status epilepticus
U2 - 10.1016/j.clinph.2022.04.003
DO - 10.1016/j.clinph.2022.04.003
M3 - Journal article
C2 - 35490437
AN - SCOPUS:85129036246
VL - 139
SP - 23
EP - 27
JO - Electroencephalography and Clinical Neurophysiology - Electromyography and Motor Control
JF - Electroencephalography and Clinical Neurophysiology - Electromyography and Motor Control
SN - 1388-2457
ER -
ID: 314074720