TY - JOUR

T1 - Edward F. Adolph distinguished lecture: muscle as an endocrine organ: IL-6 and other myokines

AU - Pedersen, Bente K

N1 - Keywords: Adipose Tissue; Animals; Autocrine Communication; Brain-Derived Neurotrophic Factor; Endocrine System; Exercise; Humans; Interleukin-15; Interleukin-6; Interleukin-8; Muscle Contraction; Muscle, Skeletal; Neovascularization, Physiologic; Paracrine Communication; Signal Transduction

PY - 2009

Y1 - 2009

N2 - Skeletal muscle is an endocrine organ that produces and releases myokines in response to contraction. Some myokines are likely to work in a hormone-like fashion, exerting specific endocrine effects on other organs such as the liver, the brain, and the fat. Other myokines will work locally via paracrine mechanisms, exerting, e.g., angiogenetic effects, whereas yet other myokines work via autocrine mechanisms and influence signaling pathways involved in fat oxidation and glucose uptake. The finding that muscles produce and release myokines creates a paradigm shift and opens new scientific, technological, and scholarly horizons. This finding represents a breakthrough within integrative physiology and contributes to our understanding of why regular exercise protects against a wide range of chronic diseases. Thus the myokine field provides a conceptual basis for the molecular mechanisms underlying, e.g., muscle-fat, muscle-liver, muscle-pancreas, and muscle-brain cross talk.

AB - Skeletal muscle is an endocrine organ that produces and releases myokines in response to contraction. Some myokines are likely to work in a hormone-like fashion, exerting specific endocrine effects on other organs such as the liver, the brain, and the fat. Other myokines will work locally via paracrine mechanisms, exerting, e.g., angiogenetic effects, whereas yet other myokines work via autocrine mechanisms and influence signaling pathways involved in fat oxidation and glucose uptake. The finding that muscles produce and release myokines creates a paradigm shift and opens new scientific, technological, and scholarly horizons. This finding represents a breakthrough within integrative physiology and contributes to our understanding of why regular exercise protects against a wide range of chronic diseases. Thus the myokine field provides a conceptual basis for the molecular mechanisms underlying, e.g., muscle-fat, muscle-liver, muscle-pancreas, and muscle-brain cross talk.

U2 - 10.1152/japplphysiol.00734.2009

DO - 10.1152/japplphysiol.00734.2009

M3 - Journal article

C2 - 19696361

VL - 107

SP - 1006

EP - 1014

JO - Journal of Applied Physiology

JF - Journal of Applied Physiology

SN - 8750-7587

IS - 4

ER -