Early Use of Antibiotics Is Associated with a Lower Incidence of Necrotizing Enterocolitis in Preterm, Very Low Birth Weight Infants: The NEOMUNE-NeoNutriNet Cohort Study

Research output: Contribution to journal › Journal article › Research › peer-review

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Early Use of Antibiotics Is Associated with a Lower Incidence of Necrotizing Enterocolitis in Preterm, Very Low Birth Weight Infants : The NEOMUNE-NeoNutriNet Cohort Study. / Li, Yanqi; Shen, René Liang; Ayede, Adejumoke I.; Berrington, Janet; Bloomfield, Frank H.; Busari, Olubunmi O.; Cormack, Barbara E.; Embleton, Nicholas D.; van Goudoever, Johannes B.; Greisen, Gorm; He, Zhongqian; Huang, Yan; Li, Xiaodong; Lin, Hung Chih; Mei, Jiaping; Meier, Paula P.; Nie, Chuan; Patel, Aloka L.; Sangild, Per T.; Skeath, Thomas; Simmer, Karen; Uhlenfeldt, Signe; de Waard, Marita; Ye, Sufen; Ye, Xuqiang; Zhang, Chunyi; Zhu, Yanna; Zhou, Ping.

In: Journal of Pediatrics, Vol. 227, 2020, p. P128-134.E2.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Li, Y, Shen, RL, Ayede, AI, Berrington, J, Bloomfield, FH, Busari, OO, Cormack, BE, Embleton, ND, van Goudoever, JB, Greisen, G, He, Z, Huang, Y, Li, X, Lin, HC, Mei, J, Meier, PP, Nie, C, Patel, AL, Sangild, PT, Skeath, T, Simmer, K, Uhlenfeldt, S, de Waard, M, Ye, S, Ye, X, Zhang, C, Zhu, Y & Zhou, P 2020, 'Early Use of Antibiotics Is Associated with a Lower Incidence of Necrotizing Enterocolitis in Preterm, Very Low Birth Weight Infants: The NEOMUNE-NeoNutriNet Cohort Study', Journal of Pediatrics, vol. 227, pp. P128-134.E2. https://doi.org/10.1016/j.jpeds.2020.06.032

APA

Li, Y., Shen, R. L., Ayede, A. I., Berrington, J., Bloomfield, F. H., Busari, O. O., Cormack, B. E., Embleton, N. D., van Goudoever, J. B., Greisen, G., He, Z., Huang, Y., Li, X., Lin, H. C., Mei, J., Meier, P. P., Nie, C., Patel, A. L., Sangild, P. T., ... Zhou, P. (2020). Early Use of Antibiotics Is Associated with a Lower Incidence of Necrotizing Enterocolitis in Preterm, Very Low Birth Weight Infants: The NEOMUNE-NeoNutriNet Cohort Study. Journal of Pediatrics, 227, P128-134.E2. https://doi.org/10.1016/j.jpeds.2020.06.032

Vancouver

Li Y, Shen RL, Ayede AI, Berrington J, Bloomfield FH, Busari OO et al. Early Use of Antibiotics Is Associated with a Lower Incidence of Necrotizing Enterocolitis in Preterm, Very Low Birth Weight Infants: The NEOMUNE-NeoNutriNet Cohort Study. Journal of Pediatrics. 2020;227:P128-134.E2. https://doi.org/10.1016/j.jpeds.2020.06.032

Author

Li, Yanqi ; Shen, René Liang ; Ayede, Adejumoke I. ; Berrington, Janet ; Bloomfield, Frank H. ; Busari, Olubunmi O. ; Cormack, Barbara E. ; Embleton, Nicholas D. ; van Goudoever, Johannes B. ; Greisen, Gorm ; He, Zhongqian ; Huang, Yan ; Li, Xiaodong ; Lin, Hung Chih ; Mei, Jiaping ; Meier, Paula P. ; Nie, Chuan ; Patel, Aloka L. ; Sangild, Per T. ; Skeath, Thomas ; Simmer, Karen ; Uhlenfeldt, Signe ; de Waard, Marita ; Ye, Sufen ; Ye, Xuqiang ; Zhang, Chunyi ; Zhu, Yanna ; Zhou, Ping. / Early Use of Antibiotics Is Associated with a Lower Incidence of Necrotizing Enterocolitis in Preterm, Very Low Birth Weight Infants : The NEOMUNE-NeoNutriNet Cohort Study. In: Journal of Pediatrics. 2020 ; Vol. 227. pp. P128-134.E2.

Bibtex

@article{28520f055ce74a4bae9f7d3508fdcf16,
title = "Early Use of Antibiotics Is Associated with a Lower Incidence of Necrotizing Enterocolitis in Preterm, Very Low Birth Weight Infants: The NEOMUNE-NeoNutriNet Cohort Study",
abstract = "Objective: To determine whether commencement of antibiotics within 3 postnatal days in preterm, very low birth weight (VLBW; ≤1500 g) infants is associated with the development of necrotizing enterocolitis (NEC). Study design: Preplanned statistical analyses were done to study the association between early antibiotic treatment and later NEC development, using the NEOMUNE-NeoNutriNet cohort of VLBW infants from 13 neonatal intensive care units (NICUs) in 5 continents (n = 2831). NEC incidence was compared between infants who received early antibiotics and those who did not, with statistical adjustments for NICU, gestational age, birth weight, sex, delivery mode, antenatal steroid use, Apgar score, and type and initiation of enteral nutrition. Results: The incidence of NEC was 9.0% in the group of infants who did not receive early antibiotics (n = 269), compared with 3.9% in those who did receive early antibiotics (n = 2562). The incidence remained lower in the early antibiotic group after stepwise statistical adjustments for NICU (OR, 0.57; 95% CI, 0.35-0.94, P <.05) and other potential confounders (OR, 0.25; 95% CI, 0.12-0.47; P <.0001). Conclusions: In this large international cohort of preterm VLBW infants, a small proportion of infants did not receive antibiotics just after birth, and these infants had a higher incidence of NEC. It is important to better understand the role of such variables as time, type, and duration of antibiotic treatment on NEC incidence, immune development, gut colonization, and antibiotic resistance in the NICU.",
author = "Yanqi Li and Shen, {Ren{\'e} Liang} and Ayede, {Adejumoke I.} and Janet Berrington and Bloomfield, {Frank H.} and Busari, {Olubunmi O.} and Cormack, {Barbara E.} and Embleton, {Nicholas D.} and {van Goudoever}, {Johannes B.} and Gorm Greisen and Zhongqian He and Yan Huang and Xiaodong Li and Lin, {Hung Chih} and Jiaping Mei and Meier, {Paula P.} and Chuan Nie and Patel, {Aloka L.} and Sangild, {Per T.} and Thomas Skeath and Karen Simmer and Signe Uhlenfeldt and {de Waard}, Marita and Sufen Ye and Xuqiang Ye and Chunyi Zhang and Yanna Zhu and Ping Zhou",
year = "2020",
doi = "10.1016/j.jpeds.2020.06.032",
language = "English",
volume = "227",
pages = "P128--134.E2",
journal = "Journal of Pediatrics",
issn = "0022-3476",
publisher = "Mosby Inc.",

}

RIS

TY - JOUR

T1 - Early Use of Antibiotics Is Associated with a Lower Incidence of Necrotizing Enterocolitis in Preterm, Very Low Birth Weight Infants

T2 - The NEOMUNE-NeoNutriNet Cohort Study

AU - Li, Yanqi

AU - Shen, René Liang

AU - Ayede, Adejumoke I.

AU - Berrington, Janet

AU - Bloomfield, Frank H.

AU - Busari, Olubunmi O.

AU - Cormack, Barbara E.

AU - Embleton, Nicholas D.

AU - van Goudoever, Johannes B.

AU - Greisen, Gorm

AU - He, Zhongqian

AU - Huang, Yan

AU - Li, Xiaodong

AU - Lin, Hung Chih

AU - Mei, Jiaping

AU - Meier, Paula P.

AU - Nie, Chuan

AU - Patel, Aloka L.

AU - Sangild, Per T.

AU - Skeath, Thomas

AU - Simmer, Karen

AU - Uhlenfeldt, Signe

AU - de Waard, Marita

AU - Ye, Sufen

AU - Ye, Xuqiang

AU - Zhang, Chunyi

AU - Zhu, Yanna

AU - Zhou, Ping

PY - 2020

Y1 - 2020

N2 - Objective: To determine whether commencement of antibiotics within 3 postnatal days in preterm, very low birth weight (VLBW; ≤1500 g) infants is associated with the development of necrotizing enterocolitis (NEC). Study design: Preplanned statistical analyses were done to study the association between early antibiotic treatment and later NEC development, using the NEOMUNE-NeoNutriNet cohort of VLBW infants from 13 neonatal intensive care units (NICUs) in 5 continents (n = 2831). NEC incidence was compared between infants who received early antibiotics and those who did not, with statistical adjustments for NICU, gestational age, birth weight, sex, delivery mode, antenatal steroid use, Apgar score, and type and initiation of enteral nutrition. Results: The incidence of NEC was 9.0% in the group of infants who did not receive early antibiotics (n = 269), compared with 3.9% in those who did receive early antibiotics (n = 2562). The incidence remained lower in the early antibiotic group after stepwise statistical adjustments for NICU (OR, 0.57; 95% CI, 0.35-0.94, P <.05) and other potential confounders (OR, 0.25; 95% CI, 0.12-0.47; P <.0001). Conclusions: In this large international cohort of preterm VLBW infants, a small proportion of infants did not receive antibiotics just after birth, and these infants had a higher incidence of NEC. It is important to better understand the role of such variables as time, type, and duration of antibiotic treatment on NEC incidence, immune development, gut colonization, and antibiotic resistance in the NICU.

AB - Objective: To determine whether commencement of antibiotics within 3 postnatal days in preterm, very low birth weight (VLBW; ≤1500 g) infants is associated with the development of necrotizing enterocolitis (NEC). Study design: Preplanned statistical analyses were done to study the association between early antibiotic treatment and later NEC development, using the NEOMUNE-NeoNutriNet cohort of VLBW infants from 13 neonatal intensive care units (NICUs) in 5 continents (n = 2831). NEC incidence was compared between infants who received early antibiotics and those who did not, with statistical adjustments for NICU, gestational age, birth weight, sex, delivery mode, antenatal steroid use, Apgar score, and type and initiation of enteral nutrition. Results: The incidence of NEC was 9.0% in the group of infants who did not receive early antibiotics (n = 269), compared with 3.9% in those who did receive early antibiotics (n = 2562). The incidence remained lower in the early antibiotic group after stepwise statistical adjustments for NICU (OR, 0.57; 95% CI, 0.35-0.94, P <.05) and other potential confounders (OR, 0.25; 95% CI, 0.12-0.47; P <.0001). Conclusions: In this large international cohort of preterm VLBW infants, a small proportion of infants did not receive antibiotics just after birth, and these infants had a higher incidence of NEC. It is important to better understand the role of such variables as time, type, and duration of antibiotic treatment on NEC incidence, immune development, gut colonization, and antibiotic resistance in the NICU.

U2 - 10.1016/j.jpeds.2020.06.032

DO - 10.1016/j.jpeds.2020.06.032

M3 - Journal article

C2 - 32553865

AN - SCOPUS:85089452948

VL - 227

SP - P128-134.E2

JO - Journal of Pediatrics

JF - Journal of Pediatrics

SN - 0022-3476

ER -

ID: 248152459