Early longitudinal changes in brain structure and cognitive functioning in remitted patients with recently diagnosed bipolar disorder
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Early longitudinal changes in brain structure and cognitive functioning in remitted patients with recently diagnosed bipolar disorder. / Macoveanu, Julian; Damgaard, Viktoria; Ysbæk-Nielsen, Alexander Tobias; Frangou, Sophia; Yatham, Lakshmi N.; Chakrabarty, Trisha; Stougaard, Marie Eschau; Knudsen, Gitte Moos; Vinberg, Maj; Kessing, Lars Vedel; Kjærstad, Hanne Lie; Miskowiak, Kamilla Woznica.
In: Journal of Affective Disorders, Vol. 339, 2023, p. 153-161.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Early longitudinal changes in brain structure and cognitive functioning in remitted patients with recently diagnosed bipolar disorder
AU - Macoveanu, Julian
AU - Damgaard, Viktoria
AU - Ysbæk-Nielsen, Alexander Tobias
AU - Frangou, Sophia
AU - Yatham, Lakshmi N.
AU - Chakrabarty, Trisha
AU - Stougaard, Marie Eschau
AU - Knudsen, Gitte Moos
AU - Vinberg, Maj
AU - Kessing, Lars Vedel
AU - Kjærstad, Hanne Lie
AU - Miskowiak, Kamilla Woznica
N1 - Publisher Copyright: © 2023
PY - 2023
Y1 - 2023
N2 - Background: Patients with bipolar disorder (BD) who are presenting with cognitive impairment and associated structural brain abnormalities have generally a poorer clinical outcome. This study aims to map the early longitudinal trajectories in brain structure and cognition in patients with recently diagnosed BD. Methods: Fully or partially remitted patients with a recent diagnosis of BD and matched healthy controls (HC) underwent structural MRI and neuropsychological testing at baseline (BD n = 97; HC n = 66) and again following an average of 16 (range 6–27) months (BD n = 50; HC n = 38). We investigated the differential trajectories in BD vs. HC in cortical gray matter volume and thickness, total cerebral white matter, hippocampal and amygdala volumes, estimated brain age, and cognitive functioning using linear mixed models. Within patients, we further investigated whether brain structural abnormalities detected at baseline were associated with subsequent mood episodes. Results: Compared to HC, patients showed a decline in total white matter volume over time and they had a larger amygdala volume, both at baseline and at follow-up time. Patients further showed lower cognitive performance at both times of investigation with no significant change over time. There were no differences between patients and HC in cortical gray matter volume or thickness, hippocampal volume, or brain-aging patterns. Conclusions: Cognitive impairment and amygdala enlargement may represent stable markers of BD early in the course of illness, whereas subtle white matter decline may result from illness progression.
AB - Background: Patients with bipolar disorder (BD) who are presenting with cognitive impairment and associated structural brain abnormalities have generally a poorer clinical outcome. This study aims to map the early longitudinal trajectories in brain structure and cognition in patients with recently diagnosed BD. Methods: Fully or partially remitted patients with a recent diagnosis of BD and matched healthy controls (HC) underwent structural MRI and neuropsychological testing at baseline (BD n = 97; HC n = 66) and again following an average of 16 (range 6–27) months (BD n = 50; HC n = 38). We investigated the differential trajectories in BD vs. HC in cortical gray matter volume and thickness, total cerebral white matter, hippocampal and amygdala volumes, estimated brain age, and cognitive functioning using linear mixed models. Within patients, we further investigated whether brain structural abnormalities detected at baseline were associated with subsequent mood episodes. Results: Compared to HC, patients showed a decline in total white matter volume over time and they had a larger amygdala volume, both at baseline and at follow-up time. Patients further showed lower cognitive performance at both times of investigation with no significant change over time. There were no differences between patients and HC in cortical gray matter volume or thickness, hippocampal volume, or brain-aging patterns. Conclusions: Cognitive impairment and amygdala enlargement may represent stable markers of BD early in the course of illness, whereas subtle white matter decline may result from illness progression.
KW - Bipolar disorder
KW - Cognition
KW - Freesurfer
KW - Longitudinal
KW - Structural MRI
KW - White matter
U2 - 10.1016/j.jad.2023.07.026
DO - 10.1016/j.jad.2023.07.026
M3 - Journal article
C2 - 37442440
AN - SCOPUS:85165239921
VL - 339
SP - 153
EP - 161
JO - Journal of Affective Disorders
JF - Journal of Affective Disorders
SN - 0165-0327
ER -
ID: 368337403