Dysregulated Lipid Metabolism Precedes Onset of Psychosis

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Dysregulated Lipid Metabolism Precedes Onset of Psychosis. / EU-GEI High Risk Study Group.

In: Biological Psychiatry, Vol. 89, No. 3, 01.02.2021, p. 288-297.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

EU-GEI High Risk Study Group 2021, 'Dysregulated Lipid Metabolism Precedes Onset of Psychosis', Biological Psychiatry, vol. 89, no. 3, pp. 288-297. https://doi.org/10.1016/j.biopsych.2020.07.012

APA

EU-GEI High Risk Study Group (2021). Dysregulated Lipid Metabolism Precedes Onset of Psychosis. Biological Psychiatry, 89(3), 288-297. https://doi.org/10.1016/j.biopsych.2020.07.012

Vancouver

EU-GEI High Risk Study Group. Dysregulated Lipid Metabolism Precedes Onset of Psychosis. Biological Psychiatry. 2021 Feb 1;89(3):288-297. https://doi.org/10.1016/j.biopsych.2020.07.012

Author

EU-GEI High Risk Study Group. / Dysregulated Lipid Metabolism Precedes Onset of Psychosis. In: Biological Psychiatry. 2021 ; Vol. 89, No. 3. pp. 288-297.

Bibtex

@article{60e705a87fa74418bd58bce8de829426,
title = "Dysregulated Lipid Metabolism Precedes Onset of Psychosis",
abstract = "Background: A key clinical challenge in the management of individuals at clinical high risk for psychosis (CHR) is that it is difficult to predict their future clinical outcomes. Here, we investigated if the levels of circulating molecular lipids are related to adverse clinical outcomes in this group. Methods: Serum lipidomic analysis was performed in 263 CHR individuals and 51 healthy control subjects, who were then clinically monitored for up to 5 years. Machine learning was used to identify lipid profiles that discriminated between CHR and control subjects, and between subgroups of CHR subjects with distinct clinical outcomes. Results: At baseline, compared with control subjects, CHR subjects (independent of outcome) had higher levels of triacylglycerols with a low acyl carbon number and a double bond count, as well as higher levels of lipids in general. CHR subjects who subsequently developed psychosis (n = 50) were distinguished from those that did not (n = 213) on the basis of lipid profile at baseline using a model with an area under the receiver operating curve of 0.81 (95% confidence interval = 0.69–0.93). CHR subjects who became psychotic had lower levels of ether phospholipids than CHR individuals who did not (p <.01). Conclusions: Collectively, these data suggest that lipidomic abnormalities predate the onset of psychosis and that blood lipidomic measures may be useful in predicting which CHR individuals are most likely to develop psychosis.",
keywords = "At-risk mental state, Clinical high risk for psychosis, Lipid metabolism, Lipidomics, Mass spectrometry, Schizophrenia",
author = "Dickens, {Alex M.} and Partho Sen and Kempton, {Matthew J.} and Neus Barrantes-Vidal and Conrad Iyegbe and Merete Nordentoft and Thomas Pollak and Anita Riecher-R{\"o}ssler and Stephan Ruhrmann and Gabriele Sachs and Rodrigo Bressan and Krebs, {Marie Odile} and Amminger, {G. Paul} and {de Haan}, Lieuwe and {van der Gaag}, Mark and Valmaggia, {Lucia R.} and Tuulia Hy{\"o}tyl{\"a}inen and Philip McGuire and Maria Calem and Stefania Tognin and Gemma Modinos and Eva Velthorst and Kraan, {Tamar C.} and {van Dam}, {Daniella S.} and Nadine Burger and Barnaby Nelson and Patrick McGorry and Christos Pantelis and Athena Politis and Joanne Goodall and Stefan Borgwardt and Charlotte Rapp and Sarah Ittig and Erich Studerus and Renata Smieskova and Ary Gadelha and Elisa Brietzke and Graccielle Asevedo and Elson Asevedo and Andre Zugman and Tecelli Dom{\'i}nguez-Mart{\'i}nez and Anna Racciopi and Kwapil, {Thomas R.} and Manel Monsonet and Araceli Rosa and Ariel Frajerman and Boris Chaumette and Julie Bourgin and Dorte Nordholm and Birte Glenth{\o}j and {EU-GEI High Risk Study Group}",
note = "Publisher Copyright: {\textcopyright} 2020 Society of Biological Psychiatry",
year = "2021",
month = feb,
day = "1",
doi = "10.1016/j.biopsych.2020.07.012",
language = "English",
volume = "89",
pages = "288--297",
journal = "Biological Psychiatry",
issn = "0006-3223",
publisher = "Elsevier",
number = "3",

}

RIS

TY - JOUR

T1 - Dysregulated Lipid Metabolism Precedes Onset of Psychosis

AU - Dickens, Alex M.

AU - Sen, Partho

AU - Kempton, Matthew J.

AU - Barrantes-Vidal, Neus

AU - Iyegbe, Conrad

AU - Nordentoft, Merete

AU - Pollak, Thomas

AU - Riecher-Rössler, Anita

AU - Ruhrmann, Stephan

AU - Sachs, Gabriele

AU - Bressan, Rodrigo

AU - Krebs, Marie Odile

AU - Amminger, G. Paul

AU - de Haan, Lieuwe

AU - van der Gaag, Mark

AU - Valmaggia, Lucia R.

AU - Hyötyläinen, Tuulia

AU - McGuire, Philip

AU - Calem, Maria

AU - Tognin, Stefania

AU - Modinos, Gemma

AU - Velthorst, Eva

AU - Kraan, Tamar C.

AU - van Dam, Daniella S.

AU - Burger, Nadine

AU - Nelson, Barnaby

AU - McGorry, Patrick

AU - Pantelis, Christos

AU - Politis, Athena

AU - Goodall, Joanne

AU - Borgwardt, Stefan

AU - Rapp, Charlotte

AU - Ittig, Sarah

AU - Studerus, Erich

AU - Smieskova, Renata

AU - Gadelha, Ary

AU - Brietzke, Elisa

AU - Asevedo, Graccielle

AU - Asevedo, Elson

AU - Zugman, Andre

AU - Domínguez-Martínez, Tecelli

AU - Racciopi, Anna

AU - Kwapil, Thomas R.

AU - Monsonet, Manel

AU - Rosa, Araceli

AU - Frajerman, Ariel

AU - Chaumette, Boris

AU - Bourgin, Julie

AU - Nordholm, Dorte

AU - Glenthøj, Birte

AU - EU-GEI High Risk Study Group

N1 - Publisher Copyright: © 2020 Society of Biological Psychiatry

PY - 2021/2/1

Y1 - 2021/2/1

N2 - Background: A key clinical challenge in the management of individuals at clinical high risk for psychosis (CHR) is that it is difficult to predict their future clinical outcomes. Here, we investigated if the levels of circulating molecular lipids are related to adverse clinical outcomes in this group. Methods: Serum lipidomic analysis was performed in 263 CHR individuals and 51 healthy control subjects, who were then clinically monitored for up to 5 years. Machine learning was used to identify lipid profiles that discriminated between CHR and control subjects, and between subgroups of CHR subjects with distinct clinical outcomes. Results: At baseline, compared with control subjects, CHR subjects (independent of outcome) had higher levels of triacylglycerols with a low acyl carbon number and a double bond count, as well as higher levels of lipids in general. CHR subjects who subsequently developed psychosis (n = 50) were distinguished from those that did not (n = 213) on the basis of lipid profile at baseline using a model with an area under the receiver operating curve of 0.81 (95% confidence interval = 0.69–0.93). CHR subjects who became psychotic had lower levels of ether phospholipids than CHR individuals who did not (p <.01). Conclusions: Collectively, these data suggest that lipidomic abnormalities predate the onset of psychosis and that blood lipidomic measures may be useful in predicting which CHR individuals are most likely to develop psychosis.

AB - Background: A key clinical challenge in the management of individuals at clinical high risk for psychosis (CHR) is that it is difficult to predict their future clinical outcomes. Here, we investigated if the levels of circulating molecular lipids are related to adverse clinical outcomes in this group. Methods: Serum lipidomic analysis was performed in 263 CHR individuals and 51 healthy control subjects, who were then clinically monitored for up to 5 years. Machine learning was used to identify lipid profiles that discriminated between CHR and control subjects, and between subgroups of CHR subjects with distinct clinical outcomes. Results: At baseline, compared with control subjects, CHR subjects (independent of outcome) had higher levels of triacylglycerols with a low acyl carbon number and a double bond count, as well as higher levels of lipids in general. CHR subjects who subsequently developed psychosis (n = 50) were distinguished from those that did not (n = 213) on the basis of lipid profile at baseline using a model with an area under the receiver operating curve of 0.81 (95% confidence interval = 0.69–0.93). CHR subjects who became psychotic had lower levels of ether phospholipids than CHR individuals who did not (p <.01). Conclusions: Collectively, these data suggest that lipidomic abnormalities predate the onset of psychosis and that blood lipidomic measures may be useful in predicting which CHR individuals are most likely to develop psychosis.

KW - At-risk mental state

KW - Clinical high risk for psychosis

KW - Lipid metabolism

KW - Lipidomics

KW - Mass spectrometry

KW - Schizophrenia

U2 - 10.1016/j.biopsych.2020.07.012

DO - 10.1016/j.biopsych.2020.07.012

M3 - Journal article

C2 - 32928501

AN - SCOPUS:85097451775

VL - 89

SP - 288

EP - 297

JO - Biological Psychiatry

JF - Biological Psychiatry

SN - 0006-3223

IS - 3

ER -

ID: 285388408