Dysfunction of Biliary Sphincter of Oddi—Clinical, Diagnostic and Treatment Challenges
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Dysfunction of Biliary Sphincter of Oddi—Clinical, Diagnostic and Treatment Challenges. / Kegnæs, Marina; Novovic, Srdan; Shabanzadeh, Daniel Mønsted.
In: Journal of Clinical Medicine, Vol. 12, No. 14, 4802, 2023.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Dysfunction of Biliary Sphincter of Oddi—Clinical, Diagnostic and Treatment Challenges
AU - Kegnæs, Marina
AU - Novovic, Srdan
AU - Shabanzadeh, Daniel Mønsted
N1 - Publisher Copyright: © 2023 by the authors.
PY - 2023
Y1 - 2023
N2 - Biliary Sphincter of Oddi dysfunction (SOD) is one of the main causes of post-cholecystectomy pain. In this review, we aimed to provide an update on the current knowledge on biliary SOD, with an emphasis on diagnostics and therapy. Overall, current but scarce data support biliary sphincterotomy for patients with type 1 and 2 SOD, but not for type 3. However, sphincterotomy is associated with post-treatment pancreatitis rates of from 10% to 15%, thus calling for improved diagnostics, patient selection and treatment modalities for SOD. The role of pharmacologic therapy for patients with SOD is poorly explored and only two randomized controlled trials are available. Currently, studies comparing treatment outcomes are few. There is an unmet need for randomized sham/placebo-controlled clinical trials related to both pharmacological and non-pharmacological treatments of SOD.
AB - Biliary Sphincter of Oddi dysfunction (SOD) is one of the main causes of post-cholecystectomy pain. In this review, we aimed to provide an update on the current knowledge on biliary SOD, with an emphasis on diagnostics and therapy. Overall, current but scarce data support biliary sphincterotomy for patients with type 1 and 2 SOD, but not for type 3. However, sphincterotomy is associated with post-treatment pancreatitis rates of from 10% to 15%, thus calling for improved diagnostics, patient selection and treatment modalities for SOD. The role of pharmacologic therapy for patients with SOD is poorly explored and only two randomized controlled trials are available. Currently, studies comparing treatment outcomes are few. There is an unmet need for randomized sham/placebo-controlled clinical trials related to both pharmacological and non-pharmacological treatments of SOD.
KW - cholecystectomy
KW - cholescintigraphy
KW - post-cholecystectomy pain
KW - sphincter of Oddi dysfunction (SOD)
KW - sphincterotomy
U2 - 10.3390/jcm12144802
DO - 10.3390/jcm12144802
M3 - Review
C2 - 37510917
AN - SCOPUS:85166284372
VL - 12
JO - Journal of Clinical Medicine
JF - Journal of Clinical Medicine
SN - 2077-0383
IS - 14
M1 - 4802
ER -
ID: 369130220