Dynamical and structural properties of lipid membranes in relation to liposomal drug delivery systems
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Dynamical and structural properties of lipid membranes in relation to liposomal drug delivery systems. / Jørgensen, Kent; Høyrup, Pernille; Pedersen, Tina B.; Mouritsen, Ole G.
In: Cellular and Molecular Biology Letters, Vol. 6, No. 2A, 2001, p. 255-263.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Dynamical and structural properties of lipid membranes in relation to liposomal drug delivery systems
AU - Jørgensen, Kent
AU - Høyrup, Pernille
AU - Pedersen, Tina B.
AU - Mouritsen, Ole G.
PY - 2001
Y1 - 2001
N2 - The structural and dynamical properties of DPPC liposomes containing lipopolymers (PEG-lipids) and charged DPPS lipids have been studied in relation to the lipid membrane interaction of enzymes and peptides. The results suggest that both the lipid membrane structure and dynamics and in particular the appearance of small-scale lipid structures might be of importance for the activity of membrane associated and liposome degrading enzymes as well as for the membrane interaction of acylated peptides. The combined experimental and simulation results are of relevance for a rational development of peptide loaded liposomal drug delivery systems that become destabilized by membrane degrading phospholipase A2 enzymes, which are found at elevated concentrations at diseased sites.
AB - The structural and dynamical properties of DPPC liposomes containing lipopolymers (PEG-lipids) and charged DPPS lipids have been studied in relation to the lipid membrane interaction of enzymes and peptides. The results suggest that both the lipid membrane structure and dynamics and in particular the appearance of small-scale lipid structures might be of importance for the activity of membrane associated and liposome degrading enzymes as well as for the membrane interaction of acylated peptides. The combined experimental and simulation results are of relevance for a rational development of peptide loaded liposomal drug delivery systems that become destabilized by membrane degrading phospholipase A2 enzymes, which are found at elevated concentrations at diseased sites.
KW - Acylated Peptides
KW - Computer Simulation
KW - Drug Delivery
KW - Fluorescence
KW - Lipid Domain
KW - Lipid Membranes
KW - PEG-Liposomes
KW - Phase Equilibria
KW - Phase Transition
KW - Phospholipase A
M3 - Journal article
C2 - 11598644
AN - SCOPUS:0034796186
VL - 6
SP - 255
EP - 263
JO - Cellular & Molecular Biology Letters
JF - Cellular & Molecular Biology Letters
SN - 1425-8153
IS - 2A
ER -
ID: 236896835