Double-blind trial of bestatin in HIV-positive patients
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Double-blind trial of bestatin in HIV-positive patients. / Hørding, M; Gøtzsche, P C; Dalh Christensen, L; Bygbjerg, Ib Christian; Faber, V.
In: Biomedicine & Pharmacotherapy, Vol. 44, No. 9, 01.01.1990, p. 475-8.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Double-blind trial of bestatin in HIV-positive patients
AU - Hørding, M
AU - Gøtzsche, P C
AU - Dalh Christensen, L
AU - Bygbjerg, Ib Christian
AU - Faber, V
PY - 1990/1/1
Y1 - 1990/1/1
N2 - Twenty-two HIV-positive homosexual men with a moderately impaired immune system were randomized to bestatin capsules 60 mg a day or placebo for 4 weeks. None suffered from opportunistic infections. The immunomodulating effect of bestatin was investigated by lymphocyte proliferation assay with pokeweed mitogen, phytohaemagglutinin, and concanavalin A, surface marker analysis of T-helper/T-suppressor cells by flow cytometry, natural killer cell activity, beta-2-microglobulin and HIV antibody quantitation. No significant differences between bestatin and placebo in immunological, haematological, biochemical or clinical variables were detected.
AB - Twenty-two HIV-positive homosexual men with a moderately impaired immune system were randomized to bestatin capsules 60 mg a day or placebo for 4 weeks. None suffered from opportunistic infections. The immunomodulating effect of bestatin was investigated by lymphocyte proliferation assay with pokeweed mitogen, phytohaemagglutinin, and concanavalin A, surface marker analysis of T-helper/T-suppressor cells by flow cytometry, natural killer cell activity, beta-2-microglobulin and HIV antibody quantitation. No significant differences between bestatin and placebo in immunological, haematological, biochemical or clinical variables were detected.
KW - Adjuvants, Immunologic
KW - Aminopeptidases
KW - Double-Blind Method
KW - HIV Infections
KW - HIV Seropositivity
KW - Humans
KW - Leucine
KW - Male
M3 - Journal article
C2 - 2081275
VL - 44
SP - 475
EP - 478
JO - Biomedicine and Pharmacotherapy
JF - Biomedicine and Pharmacotherapy
SN - 0753-3322
IS - 9
ER -
ID: 33891108