Does the release of potassium from astrocyte endfeet regulate cerebral blood flow?
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Does the release of potassium from astrocyte endfeet regulate cerebral blood flow? / Paulson, O B; Newman, E A.
In: Science (New York, N.Y.), Vol. 237, No. 4817, 21.08.1987, p. 896-8.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Does the release of potassium from astrocyte endfeet regulate cerebral blood flow?
AU - Paulson, O B
AU - Newman, E A
PY - 1987/8/21
Y1 - 1987/8/21
N2 - Local increases in neuronal activity within the brain lead to dilation of blood vessels and to increased regional cerebral blood flow. Increases in extracellular potassium concentration are known to dilate cerebral arterioles. Recent studies have suggested that the potassium released by active neurons is transported through astrocytic glial cells and released from their endfeet onto blood vessels. The results of computer simulations of potassium dynamics in the brain indicate that the release of potassium from astrocyte endfeet raises perivascular potassium concentration much more rapidly and to higher levels than does diffusion of potassium through extracellular space, particularly when the site of a potassium increase is some distance from the vessel wall. On the basis of this finding, it is proposed that the release of potassium from astrocyte endfeet plays an important role in regulating regional cerebral blood flow in response to changes in neuronal activity.
AB - Local increases in neuronal activity within the brain lead to dilation of blood vessels and to increased regional cerebral blood flow. Increases in extracellular potassium concentration are known to dilate cerebral arterioles. Recent studies have suggested that the potassium released by active neurons is transported through astrocytic glial cells and released from their endfeet onto blood vessels. The results of computer simulations of potassium dynamics in the brain indicate that the release of potassium from astrocyte endfeet raises perivascular potassium concentration much more rapidly and to higher levels than does diffusion of potassium through extracellular space, particularly when the site of a potassium increase is some distance from the vessel wall. On the basis of this finding, it is proposed that the release of potassium from astrocyte endfeet plays an important role in regulating regional cerebral blood flow in response to changes in neuronal activity.
KW - Arteries/innervation
KW - Arterioles/innervation
KW - Astrocytes/physiology
KW - Cerebrovascular Circulation
KW - Computer Simulation
KW - Potassium/physiology
KW - Regional Blood Flow
U2 - 10.1126/science.3616619
DO - 10.1126/science.3616619
M3 - Journal article
C2 - 3616619
VL - 237
SP - 896
EP - 898
JO - Science
JF - Science
SN - 0036-8075
IS - 4817
ER -
ID: 275604607