Does programmed CTL proliferation optimize virus control?

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Does programmed CTL proliferation optimize virus control? / Wodarz, Dominik; Thomsen, Allan Randrup.

In: Trends in Immunology, Vol. 26, No. 6, 2005, p. 305-10.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Wodarz, D & Thomsen, AR 2005, 'Does programmed CTL proliferation optimize virus control?', Trends in Immunology, vol. 26, no. 6, pp. 305-10. https://doi.org/10.1016/j.it.2005.04.007

APA

Wodarz, D., & Thomsen, A. R. (2005). Does programmed CTL proliferation optimize virus control? Trends in Immunology, 26(6), 305-10. https://doi.org/10.1016/j.it.2005.04.007

Vancouver

Wodarz D, Thomsen AR. Does programmed CTL proliferation optimize virus control? Trends in Immunology. 2005;26(6):305-10. https://doi.org/10.1016/j.it.2005.04.007

Author

Wodarz, Dominik ; Thomsen, Allan Randrup. / Does programmed CTL proliferation optimize virus control?. In: Trends in Immunology. 2005 ; Vol. 26, No. 6. pp. 305-10.

Bibtex

@article{5ea5baa0e16c11ddb5fc000ea68e967b,
title = "Does programmed CTL proliferation optimize virus control?",
abstract = "CD8 T-cell or cytotoxic T-lymphocyte responses develop through an antigen-independent proliferation and differentiation program. This is in contrast to the previous thinking, which was that continuous antigenic stimulation was required. This Opinion discusses why nature has chosen the proliferation program and how it compares to continuous stimulation. Although the two mechanisms should not lead to significantly different dynamics during chronic infection, they do make a difference in acute infection. We argue that programmed proliferation is better at clearance, whereas continuous stimulation is better at limiting acute symptoms. The 7-10 programmed cell divisions observed in vivo might be an optimization of this trade-off. We also discuss the conditions under which the program does or does not require CD4 T-cell help for clearance.",
author = "Dominik Wodarz and Thomsen, {Allan Randrup}",
note = "Keywords: Animals; CD4-Positive T-Lymphocytes; Cell Proliferation; T-Lymphocytes, Cytotoxic; Time Factors; Virus Diseases; Viruses",
year = "2005",
doi = "10.1016/j.it.2005.04.007",
language = "English",
volume = "26",
pages = "305--10",
journal = "Trends in Immunology",
issn = "1471-4906",
publisher = "Elsevier Ltd. * Trends Journals",
number = "6",

}

RIS

TY - JOUR

T1 - Does programmed CTL proliferation optimize virus control?

AU - Wodarz, Dominik

AU - Thomsen, Allan Randrup

N1 - Keywords: Animals; CD4-Positive T-Lymphocytes; Cell Proliferation; T-Lymphocytes, Cytotoxic; Time Factors; Virus Diseases; Viruses

PY - 2005

Y1 - 2005

N2 - CD8 T-cell or cytotoxic T-lymphocyte responses develop through an antigen-independent proliferation and differentiation program. This is in contrast to the previous thinking, which was that continuous antigenic stimulation was required. This Opinion discusses why nature has chosen the proliferation program and how it compares to continuous stimulation. Although the two mechanisms should not lead to significantly different dynamics during chronic infection, they do make a difference in acute infection. We argue that programmed proliferation is better at clearance, whereas continuous stimulation is better at limiting acute symptoms. The 7-10 programmed cell divisions observed in vivo might be an optimization of this trade-off. We also discuss the conditions under which the program does or does not require CD4 T-cell help for clearance.

AB - CD8 T-cell or cytotoxic T-lymphocyte responses develop through an antigen-independent proliferation and differentiation program. This is in contrast to the previous thinking, which was that continuous antigenic stimulation was required. This Opinion discusses why nature has chosen the proliferation program and how it compares to continuous stimulation. Although the two mechanisms should not lead to significantly different dynamics during chronic infection, they do make a difference in acute infection. We argue that programmed proliferation is better at clearance, whereas continuous stimulation is better at limiting acute symptoms. The 7-10 programmed cell divisions observed in vivo might be an optimization of this trade-off. We also discuss the conditions under which the program does or does not require CD4 T-cell help for clearance.

U2 - 10.1016/j.it.2005.04.007

DO - 10.1016/j.it.2005.04.007

M3 - Journal article

C2 - 15922946

VL - 26

SP - 305

EP - 310

JO - Trends in Immunology

JF - Trends in Immunology

SN - 1471-4906

IS - 6

ER -

ID: 9701292