Does pregnancy change the disease course? A study in a European cohort of patients with inflammatory bowel disease

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Does pregnancy change the disease course? A study in a European cohort of patients with inflammatory bowel disease. / European Collaborative Study Group on Inflammatory Bowel Disease.

In: The American Journal of Gastroenterology, Vol. 101, No. 7, 07.2006, p. 1539-45.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

European Collaborative Study Group on Inflammatory Bowel Disease 2006, 'Does pregnancy change the disease course? A study in a European cohort of patients with inflammatory bowel disease', The American Journal of Gastroenterology, vol. 101, no. 7, pp. 1539-45. https://doi.org/10.1111/j.1572-0241.2006.00602.x

APA

European Collaborative Study Group on Inflammatory Bowel Disease (2006). Does pregnancy change the disease course? A study in a European cohort of patients with inflammatory bowel disease. The American Journal of Gastroenterology, 101(7), 1539-45. https://doi.org/10.1111/j.1572-0241.2006.00602.x

Vancouver

European Collaborative Study Group on Inflammatory Bowel Disease. Does pregnancy change the disease course? A study in a European cohort of patients with inflammatory bowel disease. The American Journal of Gastroenterology. 2006 Jul;101(7):1539-45. https://doi.org/10.1111/j.1572-0241.2006.00602.x

Author

European Collaborative Study Group on Inflammatory Bowel Disease. / Does pregnancy change the disease course? A study in a European cohort of patients with inflammatory bowel disease. In: The American Journal of Gastroenterology. 2006 ; Vol. 101, No. 7. pp. 1539-45.

Bibtex

@article{c11da0891954474789c57cd48e119feb,
title = "Does pregnancy change the disease course?: A study in a European cohort of patients with inflammatory bowel disease",
abstract = "BACKGROUND AND AIMS: Inflammatory bowel disease (IBD) often affects patients in their fertile age. The aim of this study was to describe pregnancy outcome in a European cohort of IBD patients. As data are limited regarding the effect of pregnancy on disease course, our second objective was to investigate whether pregnancy influences disease course and phenotype in IBD patients.METHODS: In a European cohort of IBD patients, a 10-yr follow-up was performed by scrutinizing patient files and approaching the patients with a questionnaire. The cohort comprised 1,125 patients, of whom 543 were women. Data from 173 female ulcerative colitis (UC) and 93 Crohn's disease (CD) patients form the basis for the present study.RESULTS: In all, 580 pregnancies, 403 occurring before and 177 after IBD was diagnosed, were reported. The rate of spontaneous abortion increased after IBD was diagnosed (6.5% vs. 13%, p = 0.005), whereas elective abortion was not significantly different. 48.6% of the patients took medication at the time of conception and 46.9% during pregnancy. The use of cesarean section increased after IBD diagnosis (8.1% vs 28.7% of pregnancies). CD patients pregnant during the disease course, did not differ from patients who were not pregnant during the disease course regarding the development of stenosis (37% vs 52% p = 0.13) and resection rates (mean number of resections 0.52 vs 0.66, p = 0.37). The rate of relapse decreased in the years following pregnancy in both UC (0.34 vs 0.18 flares/yr, p = 0.008) and CD patients (0.76 vs 0.12 flares/yr, p = 0.004).CONCLUSIONS: Pregnancy did not influence disease phenotype or surgery rates, but was associated with a reduced number of flares in the following years.",
keywords = "Adult, Chi-Square Distribution, Cohort Studies, Disease Progression, Europe/epidemiology, Female, Humans, Inflammatory Bowel Diseases/epidemiology, Phenotype, Pregnancy, Pregnancy Complications/epidemiology, Pregnancy Outcome, Statistics, Nonparametric, Surveys and Questionnaires",
author = "Lene Riis and Ida Vind and Patrizia Politi and Frank Wolters and Severine Vermeire and Epameinondas Tsianos and Jo{\~a}o Freitas and Ioannis Mouzas and {Ruiz Ochoa}, Victor and Colm O'Morain and Selwyn Odes and Vibeke Binder and Bj{\o}rn Moum and Reinhold Stockbr{\"u}gger and Ebbe Langholz and Pia Munkholm and {European Collaborative Study Group on Inflammatory Bowel Disease}",
year = "2006",
month = jul,
doi = "10.1111/j.1572-0241.2006.00602.x",
language = "English",
volume = "101",
pages = "1539--45",
journal = "The American Journal of Gastroenterology",
issn = "0002-9270",
publisher = "nature publishing group",
number = "7",

}

RIS

TY - JOUR

T1 - Does pregnancy change the disease course?

T2 - A study in a European cohort of patients with inflammatory bowel disease

AU - Riis, Lene

AU - Vind, Ida

AU - Politi, Patrizia

AU - Wolters, Frank

AU - Vermeire, Severine

AU - Tsianos, Epameinondas

AU - Freitas, João

AU - Mouzas, Ioannis

AU - Ruiz Ochoa, Victor

AU - O'Morain, Colm

AU - Odes, Selwyn

AU - Binder, Vibeke

AU - Moum, Bjørn

AU - Stockbrügger, Reinhold

AU - Langholz, Ebbe

AU - Munkholm, Pia

AU - European Collaborative Study Group on Inflammatory Bowel Disease

PY - 2006/7

Y1 - 2006/7

N2 - BACKGROUND AND AIMS: Inflammatory bowel disease (IBD) often affects patients in their fertile age. The aim of this study was to describe pregnancy outcome in a European cohort of IBD patients. As data are limited regarding the effect of pregnancy on disease course, our second objective was to investigate whether pregnancy influences disease course and phenotype in IBD patients.METHODS: In a European cohort of IBD patients, a 10-yr follow-up was performed by scrutinizing patient files and approaching the patients with a questionnaire. The cohort comprised 1,125 patients, of whom 543 were women. Data from 173 female ulcerative colitis (UC) and 93 Crohn's disease (CD) patients form the basis for the present study.RESULTS: In all, 580 pregnancies, 403 occurring before and 177 after IBD was diagnosed, were reported. The rate of spontaneous abortion increased after IBD was diagnosed (6.5% vs. 13%, p = 0.005), whereas elective abortion was not significantly different. 48.6% of the patients took medication at the time of conception and 46.9% during pregnancy. The use of cesarean section increased after IBD diagnosis (8.1% vs 28.7% of pregnancies). CD patients pregnant during the disease course, did not differ from patients who were not pregnant during the disease course regarding the development of stenosis (37% vs 52% p = 0.13) and resection rates (mean number of resections 0.52 vs 0.66, p = 0.37). The rate of relapse decreased in the years following pregnancy in both UC (0.34 vs 0.18 flares/yr, p = 0.008) and CD patients (0.76 vs 0.12 flares/yr, p = 0.004).CONCLUSIONS: Pregnancy did not influence disease phenotype or surgery rates, but was associated with a reduced number of flares in the following years.

AB - BACKGROUND AND AIMS: Inflammatory bowel disease (IBD) often affects patients in their fertile age. The aim of this study was to describe pregnancy outcome in a European cohort of IBD patients. As data are limited regarding the effect of pregnancy on disease course, our second objective was to investigate whether pregnancy influences disease course and phenotype in IBD patients.METHODS: In a European cohort of IBD patients, a 10-yr follow-up was performed by scrutinizing patient files and approaching the patients with a questionnaire. The cohort comprised 1,125 patients, of whom 543 were women. Data from 173 female ulcerative colitis (UC) and 93 Crohn's disease (CD) patients form the basis for the present study.RESULTS: In all, 580 pregnancies, 403 occurring before and 177 after IBD was diagnosed, were reported. The rate of spontaneous abortion increased after IBD was diagnosed (6.5% vs. 13%, p = 0.005), whereas elective abortion was not significantly different. 48.6% of the patients took medication at the time of conception and 46.9% during pregnancy. The use of cesarean section increased after IBD diagnosis (8.1% vs 28.7% of pregnancies). CD patients pregnant during the disease course, did not differ from patients who were not pregnant during the disease course regarding the development of stenosis (37% vs 52% p = 0.13) and resection rates (mean number of resections 0.52 vs 0.66, p = 0.37). The rate of relapse decreased in the years following pregnancy in both UC (0.34 vs 0.18 flares/yr, p = 0.008) and CD patients (0.76 vs 0.12 flares/yr, p = 0.004).CONCLUSIONS: Pregnancy did not influence disease phenotype or surgery rates, but was associated with a reduced number of flares in the following years.

KW - Adult

KW - Chi-Square Distribution

KW - Cohort Studies

KW - Disease Progression

KW - Europe/epidemiology

KW - Female

KW - Humans

KW - Inflammatory Bowel Diseases/epidemiology

KW - Phenotype

KW - Pregnancy

KW - Pregnancy Complications/epidemiology

KW - Pregnancy Outcome

KW - Statistics, Nonparametric

KW - Surveys and Questionnaires

U2 - 10.1111/j.1572-0241.2006.00602.x

DO - 10.1111/j.1572-0241.2006.00602.x

M3 - Journal article

C2 - 16863558

VL - 101

SP - 1539

EP - 1545

JO - The American Journal of Gastroenterology

JF - The American Journal of Gastroenterology

SN - 0002-9270

IS - 7

ER -

ID: 219529972