TY - JOUR

T1 - Does age affect prognosis in salivary gland carcinoma patients?

T2 - A national Danish study

AU - Bjørndal, Kristine

AU - Larsen, Stine R

AU - Therkildsen, Marianne H

AU - Kristensen, Claus A

AU - Charabi, Birgitte

AU - Andersen, Elo

AU - Overgaard, Jens

AU - Schytte, Sten

AU - Pedersen, Henrik B

AU - Andersen, Lisbeth J

AU - Johansen, Jørgen

AU - Godballe, Christian

AU - Danish Head and Neck Cancer Group (DAHANCA) and Academy of Geriatric Cancer Research (AgeCare)

PY - 2016

Y1 - 2016

N2 - AIM: To compare incidence, histology, treatment modalities, disease stages, and outcome in elderly patients (≥70 years) compared to younger (<70 years).METHODS: From the national Danish salivary gland carcinoma database, 871 patients diagnosed with a primary salivary gland carcinoma from January 1990 to December 2005 were identified. Variables necessary for statistical analyses were extracted from the database.RESULTS: The younger patients have a significantly better crude, disease-specific and recurrence-free survival than the elderly ones. In univariate analysis, significantly more patients in the young group were WHO performance status 0 and in disease stage I + II, and they presented with significantly more histological low grade tumors. In multivariate analysis, chronological age seemed to be of no prognostic significance to salivary gland carcinoma patients as opposed to performance status, disease stage and histological grade.CONCLUSIONS: Salivary gland carcinoma patients over the age of 70 years have a poor prognosis compared to younger patients, which can be explained by higher disease stages, more histological high grade subtypes and a poorer performance status at the time of diagnosis.

AB - AIM: To compare incidence, histology, treatment modalities, disease stages, and outcome in elderly patients (≥70 years) compared to younger (<70 years).METHODS: From the national Danish salivary gland carcinoma database, 871 patients diagnosed with a primary salivary gland carcinoma from January 1990 to December 2005 were identified. Variables necessary for statistical analyses were extracted from the database.RESULTS: The younger patients have a significantly better crude, disease-specific and recurrence-free survival than the elderly ones. In univariate analysis, significantly more patients in the young group were WHO performance status 0 and in disease stage I + II, and they presented with significantly more histological low grade tumors. In multivariate analysis, chronological age seemed to be of no prognostic significance to salivary gland carcinoma patients as opposed to performance status, disease stage and histological grade.CONCLUSIONS: Salivary gland carcinoma patients over the age of 70 years have a poor prognosis compared to younger patients, which can be explained by higher disease stages, more histological high grade subtypes and a poorer performance status at the time of diagnosis.

KW - Adult

KW - Age Distribution

KW - Age Factors

KW - Aged

KW - Aged, 80 and over

KW - Aging

KW - Denmark

KW - Disease-Free Survival

KW - Female

KW - Humans

KW - Incidence

KW - Karnofsky Performance Status

KW - Male

KW - Middle Aged

KW - Neoplasm Grading

KW - Neoplasm Staging

KW - Prognosis

KW - Proportional Hazards Models

KW - Registries

KW - Salivary Gland Neoplasms

KW - Survival Rate

KW - Treatment Outcome

KW - Comparative Study

KW - Journal Article

U2 - 10.3109/0284186X.2015.1114671

DO - 10.3109/0284186X.2015.1114671

M3 - Journal article

C2 - 26825002

VL - 55

SP - 19

EP - 22

JO - Acta Oncologica

JF - Acta Oncologica

SN - 1100-1704

IS - Suppl 1

ER -