DNA methylation in metabolic disorders
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DNA methylation in metabolic disorders. / Barres, Romain; Zierath, Juleen R.
In: American Journal of Clinical Nutrition, Vol. 93, No. 4, 01.04.2011, p. 897S-900.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - DNA methylation in metabolic disorders
AU - Barres, Romain
AU - Zierath, Juleen R
PY - 2011/4/1
Y1 - 2011/4/1
N2 - DNA methylation is a major epigenetic modification that controls gene expression in physiologic and pathologic states. Metabolic diseases such as diabetes and obesity are associated with profound alterations in gene expression that are caused by genetic and environmental factors. Recent reports have provided evidence that environmental factors at all ages could modify DNA methylation in somatic tissues, which suggests that DNA methylation is a more dynamic process than previously appreciated. Because of the importance of lifestyle factors in metabolic disorders, DNA methylation provides a mechanism by which environmental factors, including diet and exercise, can modify genetic predisposition to disease. This article considers the current evidence that defines a role for DNA methylation in metabolic disorders.
AB - DNA methylation is a major epigenetic modification that controls gene expression in physiologic and pathologic states. Metabolic diseases such as diabetes and obesity are associated with profound alterations in gene expression that are caused by genetic and environmental factors. Recent reports have provided evidence that environmental factors at all ages could modify DNA methylation in somatic tissues, which suggests that DNA methylation is a more dynamic process than previously appreciated. Because of the importance of lifestyle factors in metabolic disorders, DNA methylation provides a mechanism by which environmental factors, including diet and exercise, can modify genetic predisposition to disease. This article considers the current evidence that defines a role for DNA methylation in metabolic disorders.
KW - DNA Methylation
KW - Diet
KW - Environment
KW - Epigenesis, Genetic
KW - Exercise
KW - Gene Expression
KW - Genetic Predisposition to Disease
KW - Humans
KW - Metabolic Diseases
U2 - 10.3945/ajcn.110.001933
DO - 10.3945/ajcn.110.001933
M3 - Review
C2 - 21289222
VL - 93
SP - 897S-900
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
SN - 0002-9165
IS - 4
ER -
ID: 35090972