DNA damage checkpoint and repair centers

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DNA damage checkpoint and repair centers. / Lisby, Michael; Rothstein, Rodney.

In: Current Opinion in Cell Biology, Vol. 16, No. 3, 06.2004, p. 328-34.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Lisby, M & Rothstein, R 2004, 'DNA damage checkpoint and repair centers', Current Opinion in Cell Biology, vol. 16, no. 3, pp. 328-34. https://doi.org/10.1016/j.ceb.2004.03.011

APA

Lisby, M., & Rothstein, R. (2004). DNA damage checkpoint and repair centers. Current Opinion in Cell Biology, 16(3), 328-34. https://doi.org/10.1016/j.ceb.2004.03.011

Vancouver

Lisby M, Rothstein R. DNA damage checkpoint and repair centers. Current Opinion in Cell Biology. 2004 Jun;16(3):328-34. https://doi.org/10.1016/j.ceb.2004.03.011

Author

Lisby, Michael ; Rothstein, Rodney. / DNA damage checkpoint and repair centers. In: Current Opinion in Cell Biology. 2004 ; Vol. 16, No. 3. pp. 328-34.

Bibtex

@article{8cab64451da6417d8f20a57c5bb453fc,
title = "DNA damage checkpoint and repair centers",
abstract = "In eukaryotes, recombinational repair is choreographed by multiprotein complexes that are organized into focal assemblies. These foci are highly dynamic giga-dalton structures capable of simultaneously repairing multiple DNA lesions. Moreover, the composition of these repair centers depends on the nature of the DNA lesion and is tightly coordinated with progression of the cell cycle. Components of DNA repair centers are regulated by post-translational modifications such as phosphorylation, ubiquitination and sumoylation. Repair foci progress through four distinct stages: first, DNA damage recognition and binding of DNA ends by the Mre11 complex and Ku70/80; second, end-processing and binding of single-stranded DNA by replication protein A, which recruits checkpoint proteins; third, recombinational repair during S and G(2) phase; and fourth, disassembly of foci and resumption of the cell cycle.",
keywords = "Animals, Cell Cycle, Cell Cycle Proteins, DNA Damage, DNA Repair, DNA Replication, Humans, Recombination, Genetic, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S., Review",
author = "Michael Lisby and Rodney Rothstein",
year = "2004",
month = jun,
doi = "10.1016/j.ceb.2004.03.011",
language = "English",
volume = "16",
pages = "328--34",
journal = "Current Opinion in Cell Biology",
issn = "0955-0674",
publisher = "Elsevier Ltd. * Current Opinion Journals",
number = "3",

}

RIS

TY - JOUR

T1 - DNA damage checkpoint and repair centers

AU - Lisby, Michael

AU - Rothstein, Rodney

PY - 2004/6

Y1 - 2004/6

N2 - In eukaryotes, recombinational repair is choreographed by multiprotein complexes that are organized into focal assemblies. These foci are highly dynamic giga-dalton structures capable of simultaneously repairing multiple DNA lesions. Moreover, the composition of these repair centers depends on the nature of the DNA lesion and is tightly coordinated with progression of the cell cycle. Components of DNA repair centers are regulated by post-translational modifications such as phosphorylation, ubiquitination and sumoylation. Repair foci progress through four distinct stages: first, DNA damage recognition and binding of DNA ends by the Mre11 complex and Ku70/80; second, end-processing and binding of single-stranded DNA by replication protein A, which recruits checkpoint proteins; third, recombinational repair during S and G(2) phase; and fourth, disassembly of foci and resumption of the cell cycle.

AB - In eukaryotes, recombinational repair is choreographed by multiprotein complexes that are organized into focal assemblies. These foci are highly dynamic giga-dalton structures capable of simultaneously repairing multiple DNA lesions. Moreover, the composition of these repair centers depends on the nature of the DNA lesion and is tightly coordinated with progression of the cell cycle. Components of DNA repair centers are regulated by post-translational modifications such as phosphorylation, ubiquitination and sumoylation. Repair foci progress through four distinct stages: first, DNA damage recognition and binding of DNA ends by the Mre11 complex and Ku70/80; second, end-processing and binding of single-stranded DNA by replication protein A, which recruits checkpoint proteins; third, recombinational repair during S and G(2) phase; and fourth, disassembly of foci and resumption of the cell cycle.

KW - Animals

KW - Cell Cycle

KW - Cell Cycle Proteins

KW - DNA Damage

KW - DNA Repair

KW - DNA Replication

KW - Humans

KW - Recombination, Genetic

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

KW - Research Support, U.S. Gov't, P.H.S.

KW - Review

U2 - 10.1016/j.ceb.2004.03.011

DO - 10.1016/j.ceb.2004.03.011

M3 - Review

C2 - 15145359

VL - 16

SP - 328

EP - 334

JO - Current Opinion in Cell Biology

JF - Current Opinion in Cell Biology

SN - 0955-0674

IS - 3

ER -

ID: 184396387