Disinfection trials with terbinafine-susceptible and terbinafine-resistant dermatophytes
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Disinfection trials with terbinafine-susceptible and terbinafine-resistant dermatophytes. / Skaastrup, Kristoffer Nagy; Astvad, Karen Marie Thyssen; Arendrup, Maiken Cavling; Jemec, Gregor Borut Ernst; Saunte, Ditte Marie Lindhardt.
In: Mycoses, Vol. 65, No. 7, 2022, p. 741-746.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Disinfection trials with terbinafine-susceptible and terbinafine-resistant dermatophytes
AU - Skaastrup, Kristoffer Nagy
AU - Astvad, Karen Marie Thyssen
AU - Arendrup, Maiken Cavling
AU - Jemec, Gregor Borut Ernst
AU - Saunte, Ditte Marie Lindhardt
N1 - Publisher Copyright: © 2022 Wiley-VCH GmbH.
PY - 2022
Y1 - 2022
N2 - Background: Treatment of tinea pedis and onychomycosis is complicated by high rates of reinfection and the emergence of terbinafine-resistant strains of Trichophyton spp. Effective disinfection of contaminated socks is an important measure. Appropriate washing reduces the risk of reinfection and is paramount in treating tinea pedis and onychomycosis. Objectives: The aim of this study was to describe the effect of commonplace disinfection methods using socks pieces inoculated with terbinafine-resistant or terbinafine-susceptible isolates of Trichophyton spp. Methods: Sock pieces were inoculated with seven terbinafine-resistant isolates of Trichophyton spp. with known mutations in the SQLE-gene (T. rubrum (n = 3), T. interdigitale (n = 1) and T. indotineae (n = 3)) and six terbinafine-susceptible isolates of Trichophyton spp. (T. rubrum (n = 3) and T. interdigitale (n = 3)). Methods of disinfection included soaking in a quaternary ammonium (QAC) detergent (0.5, 2 and 24 h), freezing at −20°C (0.5, 12 and 24 h), domestic and steam washing (both at 40°C with detergent). Sock pieces were cultured for 4 weeks following disinfection. The primary end point was no growth at the end of week 4. Results: Soaking in a QAC-detergent for 24 h procured at disinfectant rate of 100% (13/13), whilst soaking in 0.5 and 2 h had a disinfectant rate of 46.2% (6/13) and 84.6% (11/13), respectively. Domestic washing (40°C with detergent) produced a disinfectant rate of 7.7% (1/13). Freezing at −20°C (0.5, 12 and 24 h) and steam washing (40°C with detergent) had no disinfectant properties. Conclusions: Soaking in a QAC-detergent for 24 h effectively disinfected sock pieces contaminated with dermatophytes.
AB - Background: Treatment of tinea pedis and onychomycosis is complicated by high rates of reinfection and the emergence of terbinafine-resistant strains of Trichophyton spp. Effective disinfection of contaminated socks is an important measure. Appropriate washing reduces the risk of reinfection and is paramount in treating tinea pedis and onychomycosis. Objectives: The aim of this study was to describe the effect of commonplace disinfection methods using socks pieces inoculated with terbinafine-resistant or terbinafine-susceptible isolates of Trichophyton spp. Methods: Sock pieces were inoculated with seven terbinafine-resistant isolates of Trichophyton spp. with known mutations in the SQLE-gene (T. rubrum (n = 3), T. interdigitale (n = 1) and T. indotineae (n = 3)) and six terbinafine-susceptible isolates of Trichophyton spp. (T. rubrum (n = 3) and T. interdigitale (n = 3)). Methods of disinfection included soaking in a quaternary ammonium (QAC) detergent (0.5, 2 and 24 h), freezing at −20°C (0.5, 12 and 24 h), domestic and steam washing (both at 40°C with detergent). Sock pieces were cultured for 4 weeks following disinfection. The primary end point was no growth at the end of week 4. Results: Soaking in a QAC-detergent for 24 h procured at disinfectant rate of 100% (13/13), whilst soaking in 0.5 and 2 h had a disinfectant rate of 46.2% (6/13) and 84.6% (11/13), respectively. Domestic washing (40°C with detergent) produced a disinfectant rate of 7.7% (1/13). Freezing at −20°C (0.5, 12 and 24 h) and steam washing (40°C with detergent) had no disinfectant properties. Conclusions: Soaking in a QAC-detergent for 24 h effectively disinfected sock pieces contaminated with dermatophytes.
KW - dermatophytosis
KW - onychomycosis
KW - terbinafine resistance
KW - tinea
KW - Trichophyton
U2 - 10.1111/myc.13468
DO - 10.1111/myc.13468
M3 - Journal article
C2 - 35535729
AN - SCOPUS:85132122216
VL - 65
SP - 741
EP - 746
JO - Mykosen
JF - Mykosen
SN - 0933-7407
IS - 7
ER -
ID: 313501754