Differential trajectories in altered insulin sensitivity following weight loss and their impact on circulatory amino acids: Results from the PREVIEW: New Zealand Sub-study (OR27-07-19)
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Differential trajectories in altered insulin sensitivity following weight loss and their impact on circulatory amino acids : Results from the PREVIEW: New Zealand Sub-study (OR27-07-19). / Prodhan, Utpal; Milan, Amber; Silvestre, Marta; Christensen, Pia; Raben, Anne; Fogelholm, Mikael; Poppitt, Sally; Cameron-Smith, David.
In: Current Developments in Nutrition, Vol. 3, No. Suppl. 1, 2019, p. 687.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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TY - ABST
T1 - Differential trajectories in altered insulin sensitivity following weight loss and their impact on circulatory amino acids
T2 - Results from the PREVIEW: New Zealand Sub-study (OR27-07-19)
AU - Prodhan, Utpal
AU - Milan, Amber
AU - Silvestre, Marta
AU - Christensen, Pia
AU - Raben, Anne
AU - Fogelholm, Mikael
AU - Poppitt, Sally
AU - Cameron-Smith, David
N1 - CURIS 2019 NEXS 217
PY - 2019
Y1 - 2019
N2 - Objectives: Metabolite profiling studies have consistently identified altered circulatory concentrations of amino acids (AAs) in individuals with heightened risk of type 2 diabetes and cardiovascular diseases. Of the changes reported to date, the branched-chain amino acids (BCAA) may be a reliable biomarker of disease risk and have been reported to be elevated many years prior to the onset of diabetes. We hypothesised that energy restriction-associated weight loss in pre-diabetes individuals would result in altered profile of circulatory AAs, including BCAA, with the changes correlating with the improvement in insulin sensitivity.Methods: Pre-diabetic individuals (confirmed using the American Diabetes Association criteria) aged 25-70 years with BMI > 25 kg/m2 recruited into the New Zealand arm of the PREVIEW diabetes prevention trial, participated in an 8-week weight reduction program, with a requirement to lose ≥ 8% initial body weight using a commercial low-calorie diet (LCD, Cambridge Diet, UKTM). Among those who succeeded, current analysis based on available samples (n = 168) from baseline (week-0) and end of weight loss (week-8). Serum free AA concentrations measured by ultra-high pressure liquid chromatography (UPLC) and all other metabolites measured using standard assays.Results: Significant weight loss (11.1 ± 0.2% from baseline) accompanied improved insulin sensitivity and lipid profile. BCAA concentration positively correlated with insulin resistance measured at week 0 and 8, correspondingly (P < 0.05). Although the concentration of some AAs reduced significantly from week 0 to 8 (P < 0.05), reduction in fasting BCAA concentration was not significant (P > 0.05). However, regression analysis demonstrated that independent of weight loss, every 1.0 standard deviation (SD) reduction in BCAA concentration was associated with improvement in insulin sensitivity by 1.9 SD (P < 0.05).Conclusions: As expected, dietary energy restriction-associated weight loss in individuals with pre-diabetes contributes towards normalisation of insulin sensitivity. Further, the responsiveness of AA and BCAA profiles to weight loss may be beneficial for monitoring and overseeing disease risk and improvement.Funding Sources: This research was funded by the EU 7th Framework Programme; the New Zealand Health Research Council; the Food and Health Programme Seed Funding, University of Auckland; and AgResearch Limited (the Strategic Science Investment Fund). Cambridge Weight Plan, Ltd, UKTM provided the commercial LCD.
AB - Objectives: Metabolite profiling studies have consistently identified altered circulatory concentrations of amino acids (AAs) in individuals with heightened risk of type 2 diabetes and cardiovascular diseases. Of the changes reported to date, the branched-chain amino acids (BCAA) may be a reliable biomarker of disease risk and have been reported to be elevated many years prior to the onset of diabetes. We hypothesised that energy restriction-associated weight loss in pre-diabetes individuals would result in altered profile of circulatory AAs, including BCAA, with the changes correlating with the improvement in insulin sensitivity.Methods: Pre-diabetic individuals (confirmed using the American Diabetes Association criteria) aged 25-70 years with BMI > 25 kg/m2 recruited into the New Zealand arm of the PREVIEW diabetes prevention trial, participated in an 8-week weight reduction program, with a requirement to lose ≥ 8% initial body weight using a commercial low-calorie diet (LCD, Cambridge Diet, UKTM). Among those who succeeded, current analysis based on available samples (n = 168) from baseline (week-0) and end of weight loss (week-8). Serum free AA concentrations measured by ultra-high pressure liquid chromatography (UPLC) and all other metabolites measured using standard assays.Results: Significant weight loss (11.1 ± 0.2% from baseline) accompanied improved insulin sensitivity and lipid profile. BCAA concentration positively correlated with insulin resistance measured at week 0 and 8, correspondingly (P < 0.05). Although the concentration of some AAs reduced significantly from week 0 to 8 (P < 0.05), reduction in fasting BCAA concentration was not significant (P > 0.05). However, regression analysis demonstrated that independent of weight loss, every 1.0 standard deviation (SD) reduction in BCAA concentration was associated with improvement in insulin sensitivity by 1.9 SD (P < 0.05).Conclusions: As expected, dietary energy restriction-associated weight loss in individuals with pre-diabetes contributes towards normalisation of insulin sensitivity. Further, the responsiveness of AA and BCAA profiles to weight loss may be beneficial for monitoring and overseeing disease risk and improvement.Funding Sources: This research was funded by the EU 7th Framework Programme; the New Zealand Health Research Council; the Food and Health Programme Seed Funding, University of Auckland; and AgResearch Limited (the Strategic Science Investment Fund). Cambridge Weight Plan, Ltd, UKTM provided the commercial LCD.
U2 - 10.1093/cdn/nzz046.OR27-07-19
DO - 10.1093/cdn/nzz046.OR27-07-19
M3 - Conference abstract in journal
C2 - 31224824
VL - 3
SP - 687
JO - Current Developments in Nutrition
JF - Current Developments in Nutrition
SN - 2475-2991
IS - Suppl. 1
ER -
ID: 222969980