Differential effects of migraine drugs on cerebral blood flow autoregulation
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Differential effects of migraine drugs on cerebral blood flow autoregulation. / Vraamark, T; Waldemar, G; Paulson, O B.
In: Cephalalgia : an international journal of headache, Vol. 18, No. 6, 10.09.1998, p. 306-12.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Differential effects of migraine drugs on cerebral blood flow autoregulation
AU - Vraamark, T
AU - Waldemar, G
AU - Paulson, O B
PY - 1998/9/10
Y1 - 1998/9/10
N2 - The effect of the migraine drugs ergotamine and sumatriptan on the cerebral blood flow (CBF) autoregulation was studied in halothane/nitrous oxide-anesthetized normotensive Wistar Kyoto rats. Ergotamine, an ergot alkaloid affecting 5HT, norepinephrine, and dopamine receptors, was administered intravenously as a single dose of 25 microg/kg. Sumatriptan, a selective 5HT1-like receptor agonist, was administered by intravenous infusion of 300 microg/kg/h. CBF was measured with the intracarotid 133Xe-injection method. The blood pressure limits of CBF autoregulation were determined by computerized least sum of square analysis. CBF autoregulation was preserved after both ergotamine and sumatriptan. Ergotamine shifted the lower blood pressure limit of CBF autoregulation towards higher blood pressures from 60 +/- 3 mmHg to 82 +/- 4 mmHg (p<0.01), but did not significantly affect the upper blood pressure limit of CBF autoregulation. Sumatriptan had no significant effects on the blood pressure limits of CBF autoregulation.
AB - The effect of the migraine drugs ergotamine and sumatriptan on the cerebral blood flow (CBF) autoregulation was studied in halothane/nitrous oxide-anesthetized normotensive Wistar Kyoto rats. Ergotamine, an ergot alkaloid affecting 5HT, norepinephrine, and dopamine receptors, was administered intravenously as a single dose of 25 microg/kg. Sumatriptan, a selective 5HT1-like receptor agonist, was administered by intravenous infusion of 300 microg/kg/h. CBF was measured with the intracarotid 133Xe-injection method. The blood pressure limits of CBF autoregulation were determined by computerized least sum of square analysis. CBF autoregulation was preserved after both ergotamine and sumatriptan. Ergotamine shifted the lower blood pressure limit of CBF autoregulation towards higher blood pressures from 60 +/- 3 mmHg to 82 +/- 4 mmHg (p<0.01), but did not significantly affect the upper blood pressure limit of CBF autoregulation. Sumatriptan had no significant effects on the blood pressure limits of CBF autoregulation.
KW - Animals
KW - Cerebrovascular Circulation/drug effects
KW - Ergotamine/pharmacology
KW - Homeostasis/drug effects
KW - Male
KW - Rats
KW - Rats, Inbred WKY
KW - Serotonin Receptor Agonists/pharmacology
KW - Sumatriptan/pharmacology
KW - Vasoconstrictor Agents/pharmacology
U2 - 10.1046/j.1468-2982.1998.1806306.x
DO - 10.1046/j.1468-2982.1998.1806306.x
M3 - Journal article
C2 - 9731933
VL - 18
SP - 306
EP - 312
JO - Cephalalgia
JF - Cephalalgia
SN - 0800-1952
IS - 6
ER -
ID: 274964699