Dietary magnesium and cardiovascular disease: A review with emphasis in epidemiological studies
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Dietary magnesium and cardiovascular disease : A review with emphasis in epidemiological studies. / Rosique-Esteban, Nuria; Guasch-Ferré, Marta; Hernández-Alonso, Pablo; Salas-Salvadó, Jordi.
In: Nutrients, Vol. 10, No. 2, 168, 2018.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Dietary magnesium and cardiovascular disease
T2 - A review with emphasis in epidemiological studies
AU - Rosique-Esteban, Nuria
AU - Guasch-Ferré, Marta
AU - Hernández-Alonso, Pablo
AU - Salas-Salvadó, Jordi
N1 - Publisher Copyright: © 2018 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2018
Y1 - 2018
N2 - Magnesium (Mg) is an essential dietary element for humans involved in key biological processes. A growing body of evidence from epidemiological studies, randomized controlled trials (RCTs) and meta-analyses have indicated inverse associations between Mg intake and cardiovascular diseases (CVD). The present review aims to summarize recent scientific evidence on the topic, with a focus on data from epidemiological studies assessing the associations between Mg intake and major cardiovascular (CV) risk factors and CVD. We also aimed to review current literature on circulating Mg and CVD, as well as potential biological processes underlying these observations. We concluded that high Mg intake is associated with lower risk of major CV risk factors (mainly metabolic syndrome, diabetes and hypertension), stroke and total CVD. Higher levels of circulating Mg are associated with lower risk of CVD, mainly ischemic heart disease and coronary heart disease. Further, RCTs and prospective studies would help to clarify whether Mg intake and Mg circulating levels may also protect against other CVDs and CVD death.
AB - Magnesium (Mg) is an essential dietary element for humans involved in key biological processes. A growing body of evidence from epidemiological studies, randomized controlled trials (RCTs) and meta-analyses have indicated inverse associations between Mg intake and cardiovascular diseases (CVD). The present review aims to summarize recent scientific evidence on the topic, with a focus on data from epidemiological studies assessing the associations between Mg intake and major cardiovascular (CV) risk factors and CVD. We also aimed to review current literature on circulating Mg and CVD, as well as potential biological processes underlying these observations. We concluded that high Mg intake is associated with lower risk of major CV risk factors (mainly metabolic syndrome, diabetes and hypertension), stroke and total CVD. Higher levels of circulating Mg are associated with lower risk of CVD, mainly ischemic heart disease and coronary heart disease. Further, RCTs and prospective studies would help to clarify whether Mg intake and Mg circulating levels may also protect against other CVDs and CVD death.
KW - Cardiovascular
KW - Death
KW - Epidemiological studies
KW - Inflammation
KW - Magnesium
KW - Metabolic syndrome
KW - Mortality
KW - Oxidation
KW - Type 2 diabetes
U2 - 10.3390/nu10020168
DO - 10.3390/nu10020168
M3 - Review
C2 - 29389872
AN - SCOPUS:85041579943
VL - 10
JO - Nutrients
JF - Nutrients
SN - 2072-6643
IS - 2
M1 - 168
ER -
ID: 358107116