Dexrazoxane-a promising antidote in the treatment of accidental extravasation of anthracyclines
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Dexrazoxane-a promising antidote in the treatment of accidental extravasation of anthracyclines. / Jensen, Jesper Naested; Lock-Andersen, Jørgen; Langer, Seppo W; Mejer, Johannes.
In: Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery, Vol. 37, No. 3, 2003, p. 174-5.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Dexrazoxane-a promising antidote in the treatment of accidental extravasation of anthracyclines
AU - Jensen, Jesper Naested
AU - Lock-Andersen, Jørgen
AU - Langer, Seppo W
AU - Mejer, Johannes
PY - 2003
Y1 - 2003
N2 - Accidental extravasation of chemotherapy containing anthracycline often causes mutilating complications as a result of extensive tissue necrosis. Treatment therefore consists of extensive surgical debridement. We present the case of a 41-year-old woman with breast cancer who experienced extravasation of epirubicin. She was treated with an intravenous infusion of dexrazoxane for three successive days and recovered without surgical treatment and only slightly dysaesthesia in the surrounding tissue. Although infusion of dexrazoxane for this indication is still experimental we consider it a promising treatment for patients who have accidental extravasation of anthracyclines.
AB - Accidental extravasation of chemotherapy containing anthracycline often causes mutilating complications as a result of extensive tissue necrosis. Treatment therefore consists of extensive surgical debridement. We present the case of a 41-year-old woman with breast cancer who experienced extravasation of epirubicin. She was treated with an intravenous infusion of dexrazoxane for three successive days and recovered without surgical treatment and only slightly dysaesthesia in the surrounding tissue. Although infusion of dexrazoxane for this indication is still experimental we consider it a promising treatment for patients who have accidental extravasation of anthracyclines.
KW - Adult
KW - Antibiotics, Antineoplastic/administration & dosage
KW - Antineoplastic Agents/therapeutic use
KW - Breast Neoplasms/drug therapy
KW - Epirubicin/administration & dosage
KW - Extravasation of Diagnostic and Therapeutic Materials/drug therapy
KW - Female
KW - Humans
KW - Razoxane/therapeutic use
U2 - 10.1080/02844310310007791
DO - 10.1080/02844310310007791
M3 - Journal article
C2 - 12841619
VL - 37
SP - 174
EP - 175
JO - Journal of Plastic Surgery and Hand Surgery
JF - Journal of Plastic Surgery and Hand Surgery
SN - 2000-656X
IS - 3
ER -
ID: 247891831