Development of the liver: Insights into organ and tissue morphogenesis
Research output: Contribution to journal › Review › Research › peer-review
Standard
Development of the liver: Insights into organ and tissue morphogenesis. / Ober, Elke A.; Lemaigre, Frederic P.
In: Journal of Hepatology, Vol. 68, No. 5, 05.2018, p. 1049-1062.Research output: Contribution to journal › Review › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Development of the liver: Insights into organ and tissue morphogenesis
AU - Ober, Elke A.
AU - Lemaigre, Frederic P.
N1 - M1 - Copyright (C) 2018 U.S. National Library of Medicine. MEDLINE AN 2019412393(Journal; Article; (JOURNAL ARTICLE); General Review; (REVIEW))
PY - 2018/5
Y1 - 2018/5
N2 - Recent development of improved tools and methods to analyse tissues at the three-dimensional level has expanded our capacity to investigate morphogenesis of foetal liver. Here, we review the key morphogenetic steps during liver development, from the prehepatic endoderm stage to the postnatal period, and consider several model organisms while focussing on the mammalian liver. We first discuss how the liver buds out of the endoderm and gives rise to an asymmetric liver. We next outline the mechanisms driving liver and lobe growth, and review morphogenesis of the intra- and extrahepatic bile ducts; morphogenetic responses of the biliary tract to liver injury are discussed. Finally, we describe the mechanisms driving formation of the vasculature, namely venous and arterial vessels, as well as sinusoids.[on SciFinder (R)]
AB - Recent development of improved tools and methods to analyse tissues at the three-dimensional level has expanded our capacity to investigate morphogenesis of foetal liver. Here, we review the key morphogenetic steps during liver development, from the prehepatic endoderm stage to the postnatal period, and consider several model organisms while focussing on the mammalian liver. We first discuss how the liver buds out of the endoderm and gives rise to an asymmetric liver. We next outline the mechanisms driving liver and lobe growth, and review morphogenesis of the intra- and extrahepatic bile ducts; morphogenetic responses of the biliary tract to liver injury are discussed. Finally, we describe the mechanisms driving formation of the vasculature, namely venous and arterial vessels, as well as sinusoids.[on SciFinder (R)]
KW - bile duct
KW - cholangiocyte
KW - development
KW - hepatocyte
KW - liver
KW - liver growth
KW - morphogenesis
KW - organ asymmetry
KW - sinusoidal endothelial cell
KW - tissue architecture
U2 - 10.1016/j.jhep.2018.01.005
DO - 10.1016/j.jhep.2018.01.005
M3 - Review
C2 - 29339113
VL - 68
SP - 1049
EP - 1062
JO - Journal of Hepatology, Supplement
JF - Journal of Hepatology, Supplement
SN - 0169-5185
IS - 5
ER -
ID: 202773579