Derivatives of amphotericin inhibit infection with human immunodeficiency virus in vitro by different modes of action.
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Three water-soluble derivatives of amphotericin B were tested for inhibition of HIV infection in vitro. The compounds amphotericin B methyl ester (AME) and N-(N'-(2-(4'-methylmorpholinio)ethyl)N"-cyclohexyl guanyl) amphotericin B methyl ester (MCG) inhibited HIV infection by 50% at 1 microgram/ml; N-(N'-(3-dimethylaminopropyl)N"-ethyl guanyl) amphotericin B (DAPEG) did so at 5-11 micrograms/ml. While the virus-inhibitory effect of AME was due to an interaction with target lymphocytes, the effect of MCG was due to a direct anti-viral action. AME increased the potential of infected cells to fuse with uninfected cells, but MCG had no significant effect on cell fusion. All compounds had a lower cellular toxicity than amphotericin B and were not toxic at concentrations below 20 micrograms/ml.
Translated title of the contribution | Derivatives of amphotericin inhibit infection with human immunodeficiency virus in vitro by different modes of action. |
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Original language | English |
Journal | Antiviral Research |
Volume | 14 |
Issue number | 3 |
Pages (from-to) | 149-159 |
Number of pages | 11 |
ISSN | 0166-3542 |
Publication status | Published - 1990 |
ID: 34125891