Derivatives of amphotericin inhibit infection with human immunodeficiency virus in vitro by different modes of action.

Research output: Contribution to journal › Journal article › Research

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Derivatives of amphotericin inhibit infection with human immunodeficiency virus in vitro by different modes of action. / Hansen, J E; Witzke, N M; Nielsen, C; Mathiesen, Lars Reinhardt; Teglbjaerg, L S; Nielsen, C M; Nielsen, Jens Ole.

In: Antiviral Research, Vol. 14, No. 3, 1990, p. 149-159.

Research output: Contribution to journal › Journal article › Research

Harvard

Hansen, JE, Witzke, NM, Nielsen, C, Mathiesen, LR, Teglbjaerg, LS, Nielsen, CM & Nielsen, JO 1990, 'Derivatives of amphotericin inhibit infection with human immunodeficiency virus in vitro by different modes of action.', Antiviral Research, vol. 14, no. 3, pp. 149-159. <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=2080870&query_hl=103>

APA

Hansen, J. E., Witzke, N. M., Nielsen, C., Mathiesen, L. R., Teglbjaerg, L. S., Nielsen, C. M., & Nielsen, J. O. (1990). Derivatives of amphotericin inhibit infection with human immunodeficiency virus in vitro by different modes of action. Antiviral Research, 14(3), 149-159. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=2080870&query_hl=103

Vancouver

Hansen JE, Witzke NM, Nielsen C, Mathiesen LR, Teglbjaerg LS, Nielsen CM et al. Derivatives of amphotericin inhibit infection with human immunodeficiency virus in vitro by different modes of action. Antiviral Research. 1990;14(3):149-159.

Author

Hansen, J E ; Witzke, N M ; Nielsen, C ; Mathiesen, Lars Reinhardt ; Teglbjaerg, L S ; Nielsen, C M ; Nielsen, Jens Ole. / Derivatives of amphotericin inhibit infection with human immunodeficiency virus in vitro by different modes of action. In: Antiviral Research. 1990 ; Vol. 14, No. 3. pp. 149-159.

Bibtex

@article{620e471969924a64ab472dc1677f2416,
title = "Derivatives of amphotericin inhibit infection with human immunodeficiency virus in vitro by different modes of action.",
abstract = "Three water-soluble derivatives of amphotericin B were tested for inhibition of HIV infection in vitro. The compounds amphotericin B methyl ester (AME) and N-(N'-(2-(4'-methylmorpholinio)ethyl)N{"}-cyclohexyl guanyl) amphotericin B methyl ester (MCG) inhibited HIV infection by 50% at 1 microgram/ml; N-(N'-(3-dimethylaminopropyl)N{"}-ethyl guanyl) amphotericin B (DAPEG) did so at 5-11 micrograms/ml. While the virus-inhibitory effect of AME was due to an interaction with target lymphocytes, the effect of MCG was due to a direct anti-viral action. AME increased the potential of infected cells to fuse with uninfected cells, but MCG had no significant effect on cell fusion. All compounds had a lower cellular toxicity than amphotericin B and were not toxic at concentrations below 20 micrograms/ml.",
author = "Hansen, {J E} and Witzke, {N M} and C Nielsen and Mathiesen, {Lars Reinhardt} and Teglbjaerg, {L S} and Nielsen, {C M} and Nielsen, {Jens Ole}",
year = "1990",
language = "English",
volume = "14",
pages = "149--159",
journal = "Antiviral Research",
issn = "0166-3542",
publisher = "Elsevier",
number = "3",

}

RIS

TY - JOUR

T1 - Derivatives of amphotericin inhibit infection with human immunodeficiency virus in vitro by different modes of action.

AU - Hansen, J E

AU - Witzke, N M

AU - Nielsen, C

AU - Mathiesen, Lars Reinhardt

AU - Teglbjaerg, L S

AU - Nielsen, C M

AU - Nielsen, Jens Ole

PY - 1990

Y1 - 1990

N2 - Three water-soluble derivatives of amphotericin B were tested for inhibition of HIV infection in vitro. The compounds amphotericin B methyl ester (AME) and N-(N'-(2-(4'-methylmorpholinio)ethyl)N"-cyclohexyl guanyl) amphotericin B methyl ester (MCG) inhibited HIV infection by 50% at 1 microgram/ml; N-(N'-(3-dimethylaminopropyl)N"-ethyl guanyl) amphotericin B (DAPEG) did so at 5-11 micrograms/ml. While the virus-inhibitory effect of AME was due to an interaction with target lymphocytes, the effect of MCG was due to a direct anti-viral action. AME increased the potential of infected cells to fuse with uninfected cells, but MCG had no significant effect on cell fusion. All compounds had a lower cellular toxicity than amphotericin B and were not toxic at concentrations below 20 micrograms/ml.

AB - Three water-soluble derivatives of amphotericin B were tested for inhibition of HIV infection in vitro. The compounds amphotericin B methyl ester (AME) and N-(N'-(2-(4'-methylmorpholinio)ethyl)N"-cyclohexyl guanyl) amphotericin B methyl ester (MCG) inhibited HIV infection by 50% at 1 microgram/ml; N-(N'-(3-dimethylaminopropyl)N"-ethyl guanyl) amphotericin B (DAPEG) did so at 5-11 micrograms/ml. While the virus-inhibitory effect of AME was due to an interaction with target lymphocytes, the effect of MCG was due to a direct anti-viral action. AME increased the potential of infected cells to fuse with uninfected cells, but MCG had no significant effect on cell fusion. All compounds had a lower cellular toxicity than amphotericin B and were not toxic at concentrations below 20 micrograms/ml.

M3 - Journal article

VL - 14

SP - 149

EP - 159

JO - Antiviral Research

JF - Antiviral Research

SN - 0166-3542

IS - 3

ER -

ID: 34125891