Deoxynivalenol transport across the human placental barrier
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Deoxynivalenol transport across the human placental barrier. / Nielsen, Jeanette K S; Vikström, Anna C; Turner, Paul; Knudsen, Lisbeth E.
In: Food and Chemical Toxicology, Vol. 49, No. 9, 2011, p. 2046-52.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Deoxynivalenol transport across the human placental barrier
AU - Nielsen, Jeanette K S
AU - Vikström, Anna C
AU - Turner, Paul
AU - Knudsen, Lisbeth E
N1 - Copyright © 2011 Elsevier Ltd. All rights reserved.
PY - 2011
Y1 - 2011
N2 - Deoxynivalenol (DON) is the most commonly detected mycotoxin contaminant of cereal crops and cereal based food products in temperate regions of the world. DON causes adverse health effects in animals, passes through to the foetus and causes foetal abnormalities in animals. Biomonitoring for DON has revealed frequent human exposure. This study reports on DON transfer across the human placenta. Firstly, in vitro studies with the BeWo b30 clone were used as a rapid screening model showing transfer of DON through a stable confluent cell monolayer. Five term placentas were then used to study DON transfer with the ex vivo dual perfusion model. The concentration of DON on the foetal side after 4h was about 21% of that on the maternal side at t=0. These results support the data from the BeWo monolayer model in respect to the transport rate of DON, and are consistent with our hypothesis of foetal exposure to DON during pregnancy.
AB - Deoxynivalenol (DON) is the most commonly detected mycotoxin contaminant of cereal crops and cereal based food products in temperate regions of the world. DON causes adverse health effects in animals, passes through to the foetus and causes foetal abnormalities in animals. Biomonitoring for DON has revealed frequent human exposure. This study reports on DON transfer across the human placenta. Firstly, in vitro studies with the BeWo b30 clone were used as a rapid screening model showing transfer of DON through a stable confluent cell monolayer. Five term placentas were then used to study DON transfer with the ex vivo dual perfusion model. The concentration of DON on the foetal side after 4h was about 21% of that on the maternal side at t=0. These results support the data from the BeWo monolayer model in respect to the transport rate of DON, and are consistent with our hypothesis of foetal exposure to DON during pregnancy.
KW - Cell Line
KW - Enzyme-Linked Immunosorbent Assay
KW - Female
KW - Humans
KW - Maternal-Fetal Exchange
KW - Mycotoxins
KW - Placenta
KW - Pregnancy
KW - Trichothecenes
U2 - 10.1016/j.fct.2011.05.016
DO - 10.1016/j.fct.2011.05.016
M3 - Journal article
C2 - 21620924
VL - 49
SP - 2046
EP - 2052
JO - Food and Chemical Toxicology
JF - Food and Chemical Toxicology
SN - 0278-6915
IS - 9
ER -
ID: 36041519