Deoxynivalenol transport across the human placental barrier

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Deoxynivalenol transport across the human placental barrier. / Nielsen, Jeanette K S; Vikström, Anna C; Turner, Paul; Knudsen, Lisbeth E.

In: Food and Chemical Toxicology, Vol. 49, No. 9, 2011, p. 2046-52.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Nielsen, JKS, Vikström, AC, Turner, P & Knudsen, LE 2011, 'Deoxynivalenol transport across the human placental barrier', Food and Chemical Toxicology, vol. 49, no. 9, pp. 2046-52. https://doi.org/10.1016/j.fct.2011.05.016

APA

Nielsen, J. K. S., Vikström, A. C., Turner, P., & Knudsen, L. E. (2011). Deoxynivalenol transport across the human placental barrier. Food and Chemical Toxicology, 49(9), 2046-52. https://doi.org/10.1016/j.fct.2011.05.016

Vancouver

Nielsen JKS, Vikström AC, Turner P, Knudsen LE. Deoxynivalenol transport across the human placental barrier. Food and Chemical Toxicology. 2011;49(9):2046-52. https://doi.org/10.1016/j.fct.2011.05.016

Author

Nielsen, Jeanette K S ; Vikström, Anna C ; Turner, Paul ; Knudsen, Lisbeth E. / Deoxynivalenol transport across the human placental barrier. In: Food and Chemical Toxicology. 2011 ; Vol. 49, No. 9. pp. 2046-52.

Bibtex

@article{9aabf60206f2414c8c31f068d40a60f7,
title = "Deoxynivalenol transport across the human placental barrier",
abstract = "Deoxynivalenol (DON) is the most commonly detected mycotoxin contaminant of cereal crops and cereal based food products in temperate regions of the world. DON causes adverse health effects in animals, passes through to the foetus and causes foetal abnormalities in animals. Biomonitoring for DON has revealed frequent human exposure. This study reports on DON transfer across the human placenta. Firstly, in vitro studies with the BeWo b30 clone were used as a rapid screening model showing transfer of DON through a stable confluent cell monolayer. Five term placentas were then used to study DON transfer with the ex vivo dual perfusion model. The concentration of DON on the foetal side after 4h was about 21% of that on the maternal side at t=0. These results support the data from the BeWo monolayer model in respect to the transport rate of DON, and are consistent with our hypothesis of foetal exposure to DON during pregnancy.",
keywords = "Cell Line, Enzyme-Linked Immunosorbent Assay, Female, Humans, Maternal-Fetal Exchange, Mycotoxins, Placenta, Pregnancy, Trichothecenes",
author = "Nielsen, {Jeanette K S} and Vikstr{\"o}m, {Anna C} and Paul Turner and Knudsen, {Lisbeth E}",
note = "Copyright {\textcopyright} 2011 Elsevier Ltd. All rights reserved.",
year = "2011",
doi = "10.1016/j.fct.2011.05.016",
language = "English",
volume = "49",
pages = "2046--52",
journal = "Food and Chemical Toxicology",
issn = "0278-6915",
publisher = "Pergamon Press",
number = "9",

}

RIS

TY - JOUR

T1 - Deoxynivalenol transport across the human placental barrier

AU - Nielsen, Jeanette K S

AU - Vikström, Anna C

AU - Turner, Paul

AU - Knudsen, Lisbeth E

N1 - Copyright © 2011 Elsevier Ltd. All rights reserved.

PY - 2011

Y1 - 2011

N2 - Deoxynivalenol (DON) is the most commonly detected mycotoxin contaminant of cereal crops and cereal based food products in temperate regions of the world. DON causes adverse health effects in animals, passes through to the foetus and causes foetal abnormalities in animals. Biomonitoring for DON has revealed frequent human exposure. This study reports on DON transfer across the human placenta. Firstly, in vitro studies with the BeWo b30 clone were used as a rapid screening model showing transfer of DON through a stable confluent cell monolayer. Five term placentas were then used to study DON transfer with the ex vivo dual perfusion model. The concentration of DON on the foetal side after 4h was about 21% of that on the maternal side at t=0. These results support the data from the BeWo monolayer model in respect to the transport rate of DON, and are consistent with our hypothesis of foetal exposure to DON during pregnancy.

AB - Deoxynivalenol (DON) is the most commonly detected mycotoxin contaminant of cereal crops and cereal based food products in temperate regions of the world. DON causes adverse health effects in animals, passes through to the foetus and causes foetal abnormalities in animals. Biomonitoring for DON has revealed frequent human exposure. This study reports on DON transfer across the human placenta. Firstly, in vitro studies with the BeWo b30 clone were used as a rapid screening model showing transfer of DON through a stable confluent cell monolayer. Five term placentas were then used to study DON transfer with the ex vivo dual perfusion model. The concentration of DON on the foetal side after 4h was about 21% of that on the maternal side at t=0. These results support the data from the BeWo monolayer model in respect to the transport rate of DON, and are consistent with our hypothesis of foetal exposure to DON during pregnancy.

KW - Cell Line

KW - Enzyme-Linked Immunosorbent Assay

KW - Female

KW - Humans

KW - Maternal-Fetal Exchange

KW - Mycotoxins

KW - Placenta

KW - Pregnancy

KW - Trichothecenes

U2 - 10.1016/j.fct.2011.05.016

DO - 10.1016/j.fct.2011.05.016

M3 - Journal article

C2 - 21620924

VL - 49

SP - 2046

EP - 2052

JO - Food and Chemical Toxicology

JF - Food and Chemical Toxicology

SN - 0278-6915

IS - 9

ER -

ID: 36041519