Delusional disorder in old age and the risk of developing dementia: a nationwide register-based study
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Delusional disorder in old age and the risk of developing dementia: a nationwide register-based study. / Kørner, Alex; Lopez, Ana G; Lauritzen, Lise; Andersen, Per K; Kessing, Lars V.
In: Aging & Mental Health, Vol. 12, No. 5, 2008, p. 625-9.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Delusional disorder in old age and the risk of developing dementia: a nationwide register-based study
AU - Kørner, Alex
AU - Lopez, Ana G
AU - Lauritzen, Lise
AU - Andersen, Per K
AU - Kessing, Lars V
N1 - Keywords: Age Factors; Aged; Aged, 80 and over; Case-Control Studies; Dementia; Denmark; Female; Humans; Male; Middle Aged; Osteoarthritis; Poisson Distribution; Registries; Risk; Risk Assessment; Schizophrenia, Paranoid
PY - 2008
Y1 - 2008
N2 - OBJECTIVE: To examine whether very late first-contact delusional disorder carries a risk for later development of dementia. METHODS: By linkage of the psychiatric and the somatic nationwide registers of all out- and in-patients with hospital contact in Denmark, we included all 60+ patients with first ever from 1 January 1994 to 31 December 2001 with the index main diagnosis: delusional disorder. First contact osteoarthritis patients as well as the general population were used as controls. A total of 1,437 patients with persistent delusional disorder and 7,302 patients with osteoarthritis were included. Median follow-up time until first diagnosis of dementia at discharge was 1.87 and 4.40 years, respectively. The probability of getting a dementia diagnosis was estimated using Poisson regression models with dementia as the outcome of interest. RESULTS: Patients with very late first-contact delusional disorder had an 8.14 (95% CI, 6.51; 10.19) times increased rate of subsequently developing dementia compared with very late first contact osteoarthritis patients. Compared with the general population the rate ratio was 5.49 (95% CI, 4.81; 6.26). CONCLUSION: Very late first-contact delusional disorder increases the risk of subsequently getting a diagnosis of dementia 5-8 times compared with osteoarthritis patients and the general population.
AB - OBJECTIVE: To examine whether very late first-contact delusional disorder carries a risk for later development of dementia. METHODS: By linkage of the psychiatric and the somatic nationwide registers of all out- and in-patients with hospital contact in Denmark, we included all 60+ patients with first ever from 1 January 1994 to 31 December 2001 with the index main diagnosis: delusional disorder. First contact osteoarthritis patients as well as the general population were used as controls. A total of 1,437 patients with persistent delusional disorder and 7,302 patients with osteoarthritis were included. Median follow-up time until first diagnosis of dementia at discharge was 1.87 and 4.40 years, respectively. The probability of getting a dementia diagnosis was estimated using Poisson regression models with dementia as the outcome of interest. RESULTS: Patients with very late first-contact delusional disorder had an 8.14 (95% CI, 6.51; 10.19) times increased rate of subsequently developing dementia compared with very late first contact osteoarthritis patients. Compared with the general population the rate ratio was 5.49 (95% CI, 4.81; 6.26). CONCLUSION: Very late first-contact delusional disorder increases the risk of subsequently getting a diagnosis of dementia 5-8 times compared with osteoarthritis patients and the general population.
U2 - 10.1080/13607860802343118
DO - 10.1080/13607860802343118
M3 - Journal article
C2 - 18855178
VL - 12
SP - 625
EP - 629
JO - Aging & Mental Health
JF - Aging & Mental Health
SN - 1360-7863
IS - 5
ER -
ID: 10616858