Decision making and its associations to neurocognitive functions, psychopathology, and the home environment in seven-year-old children at familial high risk of schizophrenia or bipolar disorder: The Danish High Risk and Resilience Study VIA 7

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Decision making and its associations to neurocognitive functions, psychopathology, and the home environment in seven-year-old children at familial high risk of schizophrenia or bipolar disorder : The Danish High Risk and Resilience Study VIA 7. / Hemager, Nicoline; Jepsen, Jens Richardt Møllegaard; Thorup, Anne; Christiani, Camilla; Ellersgaard, Ditte; Spang, Katrine Søborg; Burton, Birgitte Klee; Gregersen, Maja; Søndergaard, Anne; Greve, Aja Neergaard; Gantriis, Ditte Lou; Mors, Ole; Nordentoft, Merete; Plessen, Kerstin J.

In: Journal of Affective Disorders, Vol. 281, 01.02.2021, p. 609-617.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Hemager, N, Jepsen, JRM, Thorup, A, Christiani, C, Ellersgaard, D, Spang, KS, Burton, BK, Gregersen, M, Søndergaard, A, Greve, AN, Gantriis, DL, Mors, O, Nordentoft, M & Plessen, KJ 2021, 'Decision making and its associations to neurocognitive functions, psychopathology, and the home environment in seven-year-old children at familial high risk of schizophrenia or bipolar disorder: The Danish High Risk and Resilience Study VIA 7', Journal of Affective Disorders, vol. 281, pp. 609-617. https://doi.org/10.1016/j.jad.2020.11.107

APA

Hemager, N., Jepsen, J. R. M., Thorup, A., Christiani, C., Ellersgaard, D., Spang, K. S., Burton, B. K., Gregersen, M., Søndergaard, A., Greve, A. N., Gantriis, D. L., Mors, O., Nordentoft, M., & Plessen, K. J. (2021). Decision making and its associations to neurocognitive functions, psychopathology, and the home environment in seven-year-old children at familial high risk of schizophrenia or bipolar disorder: The Danish High Risk and Resilience Study VIA 7. Journal of Affective Disorders, 281, 609-617. https://doi.org/10.1016/j.jad.2020.11.107

Vancouver

Hemager N, Jepsen JRM, Thorup A, Christiani C, Ellersgaard D, Spang KS et al. Decision making and its associations to neurocognitive functions, psychopathology, and the home environment in seven-year-old children at familial high risk of schizophrenia or bipolar disorder: The Danish High Risk and Resilience Study VIA 7. Journal of Affective Disorders. 2021 Feb 1;281:609-617. https://doi.org/10.1016/j.jad.2020.11.107

Author

Hemager, Nicoline ; Jepsen, Jens Richardt Møllegaard ; Thorup, Anne ; Christiani, Camilla ; Ellersgaard, Ditte ; Spang, Katrine Søborg ; Burton, Birgitte Klee ; Gregersen, Maja ; Søndergaard, Anne ; Greve, Aja Neergaard ; Gantriis, Ditte Lou ; Mors, Ole ; Nordentoft, Merete ; Plessen, Kerstin J. / Decision making and its associations to neurocognitive functions, psychopathology, and the home environment in seven-year-old children at familial high risk of schizophrenia or bipolar disorder : The Danish High Risk and Resilience Study VIA 7. In: Journal of Affective Disorders. 2021 ; Vol. 281. pp. 609-617.

Bibtex

@article{68fe44d4dae54962bcba70ea2899a2c4,
title = "Decision making and its associations to neurocognitive functions, psychopathology, and the home environment in seven-year-old children at familial high risk of schizophrenia or bipolar disorder: The Danish High Risk and Resilience Study VIA 7",
abstract = "Background: Slower and suboptimal decision making has been identified in adults with schizophrenia and bipolar disorder. Owing to the limited evidence on decision making in first-degree relatives, we aimed to investigate, whether alterations in decision making are present in young children at familial high risk of bipolar disorder or schizophrenia.Methods: In this population-based cohort study we assessed decision making in 197 children at familial high risk of schizophrenia (FHR-SZ), 115 children at familial high risk of bipolar disorder (FHR-BP), and 190 controls aged seven using the Cambridge Gambling Task. Potential associations to neurocognition, psychopathology, and the home environment were investigated.Results: Children at FHR-SZ or FHR-BP displayed intact decision making. Quality of decision making showed significant but weak cross-sectional associations to neurocognition and adequacy of the home environment. Associations to aspects of executive functions and the home environment differed across groups.Limitations: Due to the cross-sectional nature of this study, the predictive value of efficient and inefficient decision making remains to be investigated in planned follow-up studies of this cohort.Conclusions: Young children at FHR-SZ or FHR-BP do not differ from controls in decision making efficacy, which does not appear to be an early risk marker of bipolar disorder or schizophrenia. Decision making is weakly associated to neurocognition and the home environment, but not to general intelligence or psychopathology.",
author = "Nicoline Hemager and Jepsen, {Jens Richardt M{\o}llegaard} and Anne Thorup and Camilla Christiani and Ditte Ellersgaard and Spang, {Katrine S{\o}borg} and Burton, {Birgitte Klee} and Maja Gregersen and Anne S{\o}ndergaard and Greve, {Aja Neergaard} and Gantriis, {Ditte Lou} and Ole Mors and Merete Nordentoft and Plessen, {Kerstin J.}",
year = "2021",
month = feb,
day = "1",
doi = "10.1016/j.jad.2020.11.107",
language = "English",
volume = "281",
pages = "609--617",
journal = "Journal of Affective Disorders",
issn = "0165-0327",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Decision making and its associations to neurocognitive functions, psychopathology, and the home environment in seven-year-old children at familial high risk of schizophrenia or bipolar disorder

T2 - The Danish High Risk and Resilience Study VIA 7

AU - Hemager, Nicoline

AU - Jepsen, Jens Richardt Møllegaard

AU - Thorup, Anne

AU - Christiani, Camilla

AU - Ellersgaard, Ditte

AU - Spang, Katrine Søborg

AU - Burton, Birgitte Klee

AU - Gregersen, Maja

AU - Søndergaard, Anne

AU - Greve, Aja Neergaard

AU - Gantriis, Ditte Lou

AU - Mors, Ole

AU - Nordentoft, Merete

AU - Plessen, Kerstin J.

PY - 2021/2/1

Y1 - 2021/2/1

N2 - Background: Slower and suboptimal decision making has been identified in adults with schizophrenia and bipolar disorder. Owing to the limited evidence on decision making in first-degree relatives, we aimed to investigate, whether alterations in decision making are present in young children at familial high risk of bipolar disorder or schizophrenia.Methods: In this population-based cohort study we assessed decision making in 197 children at familial high risk of schizophrenia (FHR-SZ), 115 children at familial high risk of bipolar disorder (FHR-BP), and 190 controls aged seven using the Cambridge Gambling Task. Potential associations to neurocognition, psychopathology, and the home environment were investigated.Results: Children at FHR-SZ or FHR-BP displayed intact decision making. Quality of decision making showed significant but weak cross-sectional associations to neurocognition and adequacy of the home environment. Associations to aspects of executive functions and the home environment differed across groups.Limitations: Due to the cross-sectional nature of this study, the predictive value of efficient and inefficient decision making remains to be investigated in planned follow-up studies of this cohort.Conclusions: Young children at FHR-SZ or FHR-BP do not differ from controls in decision making efficacy, which does not appear to be an early risk marker of bipolar disorder or schizophrenia. Decision making is weakly associated to neurocognition and the home environment, but not to general intelligence or psychopathology.

AB - Background: Slower and suboptimal decision making has been identified in adults with schizophrenia and bipolar disorder. Owing to the limited evidence on decision making in first-degree relatives, we aimed to investigate, whether alterations in decision making are present in young children at familial high risk of bipolar disorder or schizophrenia.Methods: In this population-based cohort study we assessed decision making in 197 children at familial high risk of schizophrenia (FHR-SZ), 115 children at familial high risk of bipolar disorder (FHR-BP), and 190 controls aged seven using the Cambridge Gambling Task. Potential associations to neurocognition, psychopathology, and the home environment were investigated.Results: Children at FHR-SZ or FHR-BP displayed intact decision making. Quality of decision making showed significant but weak cross-sectional associations to neurocognition and adequacy of the home environment. Associations to aspects of executive functions and the home environment differed across groups.Limitations: Due to the cross-sectional nature of this study, the predictive value of efficient and inefficient decision making remains to be investigated in planned follow-up studies of this cohort.Conclusions: Young children at FHR-SZ or FHR-BP do not differ from controls in decision making efficacy, which does not appear to be an early risk marker of bipolar disorder or schizophrenia. Decision making is weakly associated to neurocognition and the home environment, but not to general intelligence or psychopathology.

U2 - 10.1016/j.jad.2020.11.107

DO - 10.1016/j.jad.2020.11.107

M3 - Journal article

C2 - 33257040

VL - 281

SP - 609

EP - 617

JO - Journal of Affective Disorders

JF - Journal of Affective Disorders

SN - 0165-0327

ER -

ID: 282745666