Cortico-cognition coupling in treatment resistant schizophrenia
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Cortico-cognition coupling in treatment resistant schizophrenia. / Syeda, Warda T.; Wannan, Cassandra M.J.; Merritt, Antonia H.; Raghava, Jayachandra M.; Jayaram, Mahesh; Velakoulis, Dennis; Kristensen, Tina D.; Soldatos, Rigas Filippos; Tonissen, Shane; Thomas, Naveen; Ambrosen, Karen S.; Sørensen, Mikkel E.; Fagerlund, Birgitte; Rostrup, Egill; Glenthøj, Birte Y.; Skafidas, Efstratios; Bousman, Chad A.; Johnston, Leigh A.; Everall, Ian; Ebdrup, Bjørn H.; Pantelis, Christos.
In: NeuroImage: Clinical, Vol. 35, 103064, 2022.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Cortico-cognition coupling in treatment resistant schizophrenia
AU - Syeda, Warda T.
AU - Wannan, Cassandra M.J.
AU - Merritt, Antonia H.
AU - Raghava, Jayachandra M.
AU - Jayaram, Mahesh
AU - Velakoulis, Dennis
AU - Kristensen, Tina D.
AU - Soldatos, Rigas Filippos
AU - Tonissen, Shane
AU - Thomas, Naveen
AU - Ambrosen, Karen S.
AU - Sørensen, Mikkel E.
AU - Fagerlund, Birgitte
AU - Rostrup, Egill
AU - Glenthøj, Birte Y.
AU - Skafidas, Efstratios
AU - Bousman, Chad A.
AU - Johnston, Leigh A.
AU - Everall, Ian
AU - Ebdrup, Bjørn H.
AU - Pantelis, Christos
N1 - Publisher Copyright: © 2022 The Authors
PY - 2022
Y1 - 2022
N2 - Background: Brain structural alterations and cognitive dysfunction are independent predictors for poor clinical outcome in schizophrenia, and the associations between these domains remains unclear. We employed a novel, multiblock partial least squares correlation (MB-PLS-C) technique and investigated multivariate cortico-cognitive patterns in patients with treatment-resistant schizophrenia (TRS) and matched healthy controls (HC). Method: Forty-one TRS patients (age 38.5 ± 9.1, 30 males (M)), and 45 HC (age 40.2 ± 10.6, 29 M) underwent 3T structural MRI. Volumes of 68 brain regions and seven variables from CANTAB covering memory and executive domains were included. Univariate group differences were assessed, followed by the MB-PLS-C analyses to identify group-specific multivariate patterns of cortico-cognitive coupling. Supplementary three-group analyses, which included 23 non-affected first-degree relatives (NAR), were also conducted. Results: Univariate tests demonstrated that TRS patients showed impairments in all seven cognitive tasks and volume reductions in 12 cortical regions following Bonferroni correction. The MB-PLS-C analyses revealed two significant latent variables (LVs) explaining > 90% of the sum-of-squares variance. LV1 explained 78.86% of the sum-of-squares variance, describing a shared, widespread structure-cognitive pattern relevant to both TRS patients and HCs. In contrast, LV2 (13.47% of sum-of-squares variance explained) appeared specific to TRS and comprised a differential cortico-cognitive pattern including frontal and temporal lobes as well as paired associates learning (PAL) and intra-extra dimensional set shifting (IED). Three-group analyses also identified two significant LVs, with NARs more closely resembling healthy controls than TRS patients. Conclusions: MB-PLS-C analyses identified multivariate brain structural-cognitive patterns in the latent space that may provide a TRS signature.
AB - Background: Brain structural alterations and cognitive dysfunction are independent predictors for poor clinical outcome in schizophrenia, and the associations between these domains remains unclear. We employed a novel, multiblock partial least squares correlation (MB-PLS-C) technique and investigated multivariate cortico-cognitive patterns in patients with treatment-resistant schizophrenia (TRS) and matched healthy controls (HC). Method: Forty-one TRS patients (age 38.5 ± 9.1, 30 males (M)), and 45 HC (age 40.2 ± 10.6, 29 M) underwent 3T structural MRI. Volumes of 68 brain regions and seven variables from CANTAB covering memory and executive domains were included. Univariate group differences were assessed, followed by the MB-PLS-C analyses to identify group-specific multivariate patterns of cortico-cognitive coupling. Supplementary three-group analyses, which included 23 non-affected first-degree relatives (NAR), were also conducted. Results: Univariate tests demonstrated that TRS patients showed impairments in all seven cognitive tasks and volume reductions in 12 cortical regions following Bonferroni correction. The MB-PLS-C analyses revealed two significant latent variables (LVs) explaining > 90% of the sum-of-squares variance. LV1 explained 78.86% of the sum-of-squares variance, describing a shared, widespread structure-cognitive pattern relevant to both TRS patients and HCs. In contrast, LV2 (13.47% of sum-of-squares variance explained) appeared specific to TRS and comprised a differential cortico-cognitive pattern including frontal and temporal lobes as well as paired associates learning (PAL) and intra-extra dimensional set shifting (IED). Three-group analyses also identified two significant LVs, with NARs more closely resembling healthy controls than TRS patients. Conclusions: MB-PLS-C analyses identified multivariate brain structural-cognitive patterns in the latent space that may provide a TRS signature.
KW - Brain structure
KW - Cognition
KW - MRI
KW - Partial least squares correlation
KW - Treatment-resistant schizophrenia
UR - http://www.scopus.com/inward/record.url?scp=85131963805&partnerID=8YFLogxK
U2 - 10.1016/j.nicl.2022.103064
DO - 10.1016/j.nicl.2022.103064
M3 - Journal article
C2 - 35689976
AN - SCOPUS:85131963805
VL - 35
JO - NeuroImage: Clinical
JF - NeuroImage: Clinical
SN - 2213-1582
M1 - 103064
ER -
ID: 330468059