Coronary Artery Disease in Persons with Human Immunodeficiency Virus Without Detectable Viral Replication
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Coronary Artery Disease in Persons with Human Immunodeficiency Virus Without Detectable Viral Replication. / Knudsen, Andreas D.; Fuchs, Andreas; Benfield, Thomas; Gerstoft, Jan; Køber, Lars; Trøseid, Marius; Kofoed, Klaus F.; Nielsen, Susanne D.
In: Open Forum Infectious Diseases, Vol. 10, No. 7, ofad298, 2023.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Coronary Artery Disease in Persons with Human Immunodeficiency Virus Without Detectable Viral Replication
AU - Knudsen, Andreas D.
AU - Fuchs, Andreas
AU - Benfield, Thomas
AU - Gerstoft, Jan
AU - Køber, Lars
AU - Trøseid, Marius
AU - Kofoed, Klaus F.
AU - Nielsen, Susanne D.
N1 - Publisher Copyright: © 2023 The Author(s). Published by Oxford University Press on behalf of Infectious Diseases Society of America.
PY - 2023
Y1 - 2023
N2 - Background: We aimed to determine the prevalence of coronary artery disease (CAD) in persons with human immunodeficiency virus (HIV; PWH) and investigate whether inflammatory markers, including interleukin 6, IL-1β, and high-sensitivity C-reactive protein (hsCRP), were associated with CAD. Methods: From the Copenhagen Comorbidity in HIV Infection (COCOMO) study, we included virologically suppressed PWH who underwent coronary computed tomographic (CT) angiography. Any atherosclerosis was defined as >0% stenosis, and obstructive CAD as ≥50% stenosis. Results: Among 669 participants (mean age [standard deviation], 51 [11] years; 89% male), 300 (45%) had atherosclerosis, and 119 (18%) had obstructive CAD. The following risk factors were associated with any atherosclerosis and with obstructive CAD: Age, male sex, hypertension, diabetes, smoking, dyslipidemia, time with HIV, and current protease inhibitor use. Interleukin 6 (IL-6) and hsCRP levels >2âmg/L were associated with any atherosclerosis and with obstructive CAD in univariable analyses but not after adjustment for traditional risk factors. IL-1β was not associated with CAD. Conclusions: In a large population of PWH without viral replication, almost half had angiographically verified atherosclerosis. High concentrations of IL-6 and hsCRP were associated with CAD in univariable analyses, but adjustment for cardiovascular risk factors attenuated the association, suggesting that inflammation may mediate the association between traditional risk factors and CAD.
AB - Background: We aimed to determine the prevalence of coronary artery disease (CAD) in persons with human immunodeficiency virus (HIV; PWH) and investigate whether inflammatory markers, including interleukin 6, IL-1β, and high-sensitivity C-reactive protein (hsCRP), were associated with CAD. Methods: From the Copenhagen Comorbidity in HIV Infection (COCOMO) study, we included virologically suppressed PWH who underwent coronary computed tomographic (CT) angiography. Any atherosclerosis was defined as >0% stenosis, and obstructive CAD as ≥50% stenosis. Results: Among 669 participants (mean age [standard deviation], 51 [11] years; 89% male), 300 (45%) had atherosclerosis, and 119 (18%) had obstructive CAD. The following risk factors were associated with any atherosclerosis and with obstructive CAD: Age, male sex, hypertension, diabetes, smoking, dyslipidemia, time with HIV, and current protease inhibitor use. Interleukin 6 (IL-6) and hsCRP levels >2âmg/L were associated with any atherosclerosis and with obstructive CAD in univariable analyses but not after adjustment for traditional risk factors. IL-1β was not associated with CAD. Conclusions: In a large population of PWH without viral replication, almost half had angiographically verified atherosclerosis. High concentrations of IL-6 and hsCRP were associated with CAD in univariable analyses, but adjustment for cardiovascular risk factors attenuated the association, suggesting that inflammation may mediate the association between traditional risk factors and CAD.
KW - CCTA
KW - comorbidity
KW - coronary artery disease
KW - HIV
KW - inflammation
U2 - 10.1093/ofid/ofad298
DO - 10.1093/ofid/ofad298
M3 - Journal article
C2 - 37441354
AN - SCOPUS:85166104201
VL - 10
JO - Open Forum Infectious Diseases
JF - Open Forum Infectious Diseases
SN - 2328-8957
IS - 7
M1 - ofad298
ER -
ID: 367902928