Cooling of Medial Septum Reveals Theta Phase Lag Coordination of Hippocampal Cell Assemblies

Research output: Contribution to journal › Journal article › Research › peer-review

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Cooling of Medial Septum Reveals Theta Phase Lag Coordination of Hippocampal Cell Assemblies. / Petersen, Peter C.; Buzsáki, György.

In: Neuron, Vol. 107, No. 4, 2020, p. 731-744.e3.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Petersen, PC & Buzsáki, G 2020, 'Cooling of Medial Septum Reveals Theta Phase Lag Coordination of Hippocampal Cell Assemblies', Neuron, vol. 107, no. 4, pp. 731-744.e3. https://doi.org/10.1016/j.neuron.2020.05.023

APA

Petersen, P. C., & Buzsáki, G. (2020). Cooling of Medial Septum Reveals Theta Phase Lag Coordination of Hippocampal Cell Assemblies. Neuron, 107(4), 731-744.e3. https://doi.org/10.1016/j.neuron.2020.05.023

Vancouver

Petersen PC, Buzsáki G. Cooling of Medial Septum Reveals Theta Phase Lag Coordination of Hippocampal Cell Assemblies. Neuron. 2020;107(4):731-744.e3. https://doi.org/10.1016/j.neuron.2020.05.023

Author

Petersen, Peter C. ; Buzsáki, György. / Cooling of Medial Septum Reveals Theta Phase Lag Coordination of Hippocampal Cell Assemblies. In: Neuron. 2020 ; Vol. 107, No. 4. pp. 731-744.e3.

Bibtex

@article{0b290eb9ed0c42a58ef6781184a99d96,

title = "Cooling of Medial Septum Reveals Theta Phase Lag Coordination of Hippocampal Cell Assemblies",

abstract = "Hippocampal theta oscillations coordinate neuronal firing to support memory and spatial navigation. The medial septum (MS) is critical in theta generation by two possible mechanisms: either a unitary {"}pacemaker{"} timing signal is imposed on the hippocampal system, or it may assist in organizing target subcircuits within the phase space of theta oscillations. We used temperature manipulation of the MS to test these models. Cooling of the MS reduced both theta frequency and power and was associated with an enhanced incidence of errors in a spatial navigation task, but it did not affect spatial correlates of neurons. MS cooling decreased theta frequency oscillations of place cells and reduced distance-time compression but preserved distance-phase compression of place field sequences within the theta cycle. Thus, the septum is critical for sustaining precise theta phase coordination of cell assemblies in the hippocampal system, a mechanism needed for spatial memory.",

keywords = "Action Potentials/physiology, Animals, Cold Temperature, Hippocampus/physiology, Male, Models, Neurological, Neurons/physiology, Place Cells/physiology, Rats, Rats, Long-Evans, Septal Nuclei/physiology, Spatial Memory/physiology, Theta Rhythm/physiology",

author = "Petersen, {Peter C.} and Gy{\"o}rgy Buzs{\'a}ki",

year = "2020",

doi = "10.1016/j.neuron.2020.05.023",

language = "English",

volume = "107",

pages = "731--744.e3",

journal = "Neuron",

issn = "0896-6273",

publisher = "Cell Press",

number = "4",

}

RIS

TY - JOUR

T1 - Cooling of Medial Septum Reveals Theta Phase Lag Coordination of Hippocampal Cell Assemblies

AU - Petersen, Peter C.

AU - Buzsáki, György

PY - 2020

Y1 - 2020

N2 - Hippocampal theta oscillations coordinate neuronal firing to support memory and spatial navigation. The medial septum (MS) is critical in theta generation by two possible mechanisms: either a unitary "pacemaker" timing signal is imposed on the hippocampal system, or it may assist in organizing target subcircuits within the phase space of theta oscillations. We used temperature manipulation of the MS to test these models. Cooling of the MS reduced both theta frequency and power and was associated with an enhanced incidence of errors in a spatial navigation task, but it did not affect spatial correlates of neurons. MS cooling decreased theta frequency oscillations of place cells and reduced distance-time compression but preserved distance-phase compression of place field sequences within the theta cycle. Thus, the septum is critical for sustaining precise theta phase coordination of cell assemblies in the hippocampal system, a mechanism needed for spatial memory.

AB - Hippocampal theta oscillations coordinate neuronal firing to support memory and spatial navigation. The medial septum (MS) is critical in theta generation by two possible mechanisms: either a unitary "pacemaker" timing signal is imposed on the hippocampal system, or it may assist in organizing target subcircuits within the phase space of theta oscillations. We used temperature manipulation of the MS to test these models. Cooling of the MS reduced both theta frequency and power and was associated with an enhanced incidence of errors in a spatial navigation task, but it did not affect spatial correlates of neurons. MS cooling decreased theta frequency oscillations of place cells and reduced distance-time compression but preserved distance-phase compression of place field sequences within the theta cycle. Thus, the septum is critical for sustaining precise theta phase coordination of cell assemblies in the hippocampal system, a mechanism needed for spatial memory.

KW - Action Potentials/physiology

KW - Animals

KW - Cold Temperature

KW - Hippocampus/physiology

KW - Male

KW - Models, Neurological

KW - Neurons/physiology

KW - Place Cells/physiology

KW - Rats

KW - Rats, Long-Evans

KW - Septal Nuclei/physiology

KW - Spatial Memory/physiology

KW - Theta Rhythm/physiology

U2 - 10.1016/j.neuron.2020.05.023

DO - 10.1016/j.neuron.2020.05.023

M3 - Journal article

C2 - 32526196

VL - 107

SP - 731-744.e3

JO - Neuron

JF - Neuron

SN - 0896-6273

IS - 4

ER -

ID: 339356023

Forskning