Conjoined twins after single blastocyst transfer: a case report including detailed time-lapse recording of the earliest embryogenesis, from zygote to expanded blastocyst
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Conjoined twins after single blastocyst transfer : a case report including detailed time-lapse recording of the earliest embryogenesis, from zygote to expanded blastocyst. / Grondahl, Marie Louise; Tharin, Julie Elisabeth; Maroun, Lisa Leth; Jorgensen, Finn Stener.
In: Human Reproduction, Vol. 37, No. 4, 2022, p. 718-724.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Conjoined twins after single blastocyst transfer
T2 - a case report including detailed time-lapse recording of the earliest embryogenesis, from zygote to expanded blastocyst
AU - Grondahl, Marie Louise
AU - Tharin, Julie Elisabeth
AU - Maroun, Lisa Leth
AU - Jorgensen, Finn Stener
PY - 2022
Y1 - 2022
N2 - Conjoined twins are estimated to occur in 1:50 000 pregnancies. Eighteen cases of pregnancies achieved by ART have been published of which three were achieved after single embryo transfer, allowing discussion of embryo characteristics. We report, to the best of our knowledge, the first case of parapagus conjoined twins after ART. Furthermore, this is the first report of conjoined twins with detailed morphokinetics of the earliest embryogenesis from zygote to expanded and hatched blastocyst stage. The case zygote had three refractile bodies, which were all allocated to one blastomere at first cleavage following an asynchronous pronuclei fading. Within 2 h, this blastomere cleaved to four and fragmented. The remaining blastomere cleaved symmetrically and regularly and a blastocyst (score: 4AB) was vitrified 120 h after IVF. Pregnancy was achieved following a frozen-thawed single blastocyst transfer. The etiopathogenetic mechanism of the origin of conjoined twins is unknown and several hypotheses exist. The morphokinetics in the present case and morphology of other reported cases will be discussed in this context.
AB - Conjoined twins are estimated to occur in 1:50 000 pregnancies. Eighteen cases of pregnancies achieved by ART have been published of which three were achieved after single embryo transfer, allowing discussion of embryo characteristics. We report, to the best of our knowledge, the first case of parapagus conjoined twins after ART. Furthermore, this is the first report of conjoined twins with detailed morphokinetics of the earliest embryogenesis from zygote to expanded and hatched blastocyst stage. The case zygote had three refractile bodies, which were all allocated to one blastomere at first cleavage following an asynchronous pronuclei fading. Within 2 h, this blastomere cleaved to four and fragmented. The remaining blastomere cleaved symmetrically and regularly and a blastocyst (score: 4AB) was vitrified 120 h after IVF. Pregnancy was achieved following a frozen-thawed single blastocyst transfer. The etiopathogenetic mechanism of the origin of conjoined twins is unknown and several hypotheses exist. The morphokinetics in the present case and morphology of other reported cases will be discussed in this context.
KW - blastocyst
KW - morphokinetics
KW - time-lapse recording
KW - conjoined twins
KW - asynchronous pronuclei fading
KW - asymmetric division
KW - IN-VITRO FERTILIZATION
KW - TRIPLET PREGNANCY
KW - 1ST-TRIMESTER DIAGNOSIS
KW - IVF
KW - ANNOTATION
KW - FETUSES
KW - STAGE
KW - RISK
U2 - 10.1093/humrep/deac004
DO - 10.1093/humrep/deac004
M3 - Journal article
C2 - 35134933
VL - 37
SP - 718
EP - 724
JO - Human Reproduction
JF - Human Reproduction
SN - 0268-1161
IS - 4
ER -
ID: 308113706