Confirmatory analysis of survival data using left truncation of the life times of primary survivors
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Confirmatory analysis of survival data using left truncation of the life times of primary survivors. / Keiding, Niels; Bayer, Thomas; Watt‐Boolsen, Steen.
In: Statistics in Medicine, Vol. 6, No. 8, 12.1987, p. 939-944.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Confirmatory analysis of survival data using left truncation of the life times of primary survivors
AU - Keiding, Niels
AU - Bayer, Thomas
AU - Watt‐Boolsen, Steen
PY - 1987/12
Y1 - 1987/12
N2 - In survival analysis, as in other branches of applied statistics, confirmatory analysis is often requested before an initial finding can be cleared of suspicion of being due just to mass significance. This paper points out that the special temporal structure of the classical clinical trial with staggered entry allows re‐use of the initial survivors by left‐truncating their remaining survival times. This procedure can often save a considerable amount of calendar time. The procedure is illustrated by data from the Danish Breast Cancer Cooperative Group.
AB - In survival analysis, as in other branches of applied statistics, confirmatory analysis is often requested before an initial finding can be cleared of suspicion of being due just to mass significance. This paper points out that the special temporal structure of the classical clinical trial with staggered entry allows re‐use of the initial survivors by left‐truncating their remaining survival times. This procedure can often save a considerable amount of calendar time. The procedure is illustrated by data from the Danish Breast Cancer Cooperative Group.
KW - Breast cancer
KW - Censored observations
KW - Confirmatory analysis
KW - Data splitting
KW - Interim analysis
KW - Left truncation
KW - Mass significance
KW - Survival analysis
UR - http://www.scopus.com/inward/record.url?scp=0023481220&partnerID=8YFLogxK
U2 - 10.1002/sim.4780060808
DO - 10.1002/sim.4780060808
M3 - Journal article
C2 - 3438619
AN - SCOPUS:0023481220
VL - 6
SP - 939
EP - 944
JO - Statistics in Medicine
JF - Statistics in Medicine
SN - 0277-6715
IS - 8
ER -
ID: 202336256