Concepts and introduction to RNA bioinformatics
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Concepts and introduction to RNA bioinformatics. / Gorodkin, Jan; Hofacker, Ivo L.; Ruzzo, Walter L.
In: Methods in molecular biology (Clifton, N.J.), Vol. 1097, 2014, p. 1-31.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Concepts and introduction to RNA bioinformatics
AU - Gorodkin, Jan
AU - Hofacker, Ivo L.
AU - Ruzzo, Walter L.
PY - 2014
Y1 - 2014
N2 - RNA bioinformatics and computational RNA biology have emerged from implementing methods for predicting the secondary structure of single sequences. The field has evolved to exploit multiple sequences to take evolutionary information into account, such as compensating (and structure preserving) base changes. These methods have been developed further and applied for computational screens of genomic sequence. Furthermore, a number of additional directions have emerged. These include methods to search for RNA 3D structure, RNA-RNA interactions, and design of interfering RNAs (RNAi) as well as methods for interactions between RNA and proteins.Here, we introduce the basic concepts of predicting RNA secondary structure relevant to the further analyses of RNA sequences. We also provide pointers to methods addressing various aspects of RNA bioinformatics and computational RNA biology.
AB - RNA bioinformatics and computational RNA biology have emerged from implementing methods for predicting the secondary structure of single sequences. The field has evolved to exploit multiple sequences to take evolutionary information into account, such as compensating (and structure preserving) base changes. These methods have been developed further and applied for computational screens of genomic sequence. Furthermore, a number of additional directions have emerged. These include methods to search for RNA 3D structure, RNA-RNA interactions, and design of interfering RNAs (RNAi) as well as methods for interactions between RNA and proteins.Here, we introduce the basic concepts of predicting RNA secondary structure relevant to the further analyses of RNA sequences. We also provide pointers to methods addressing various aspects of RNA bioinformatics and computational RNA biology.
KW - Algorithms
KW - Computational Biology
KW - Nucleic Acid Conformation
KW - RNA
KW - RNA Folding
U2 - 10.1007/978-1-62703-709-9_1
DO - 10.1007/978-1-62703-709-9_1
M3 - Journal article
C2 - 24639152
VL - 1097
SP - 1
EP - 31
JO - Methods in Molecular Biology
JF - Methods in Molecular Biology
SN - 1064-3745
ER -
ID: 138722755