Concanavalin-A-activated suppressor cells in patients with juvenile rheumatoid arthritis
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Concanavalin-A-activated suppressor cells in patients with juvenile rheumatoid arthritis. / Astrup, L B; Morling, N; Ryder, L P; Friis, J; Pedersen, F K; Svejgaard, A.
In: Scandinavian Journal of Immunology, Vol. 16, No. 5, 1982, p. 361-7.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Concanavalin-A-activated suppressor cells in patients with juvenile rheumatoid arthritis
AU - Astrup, L B
AU - Morling, N
AU - Ryder, L P
AU - Friis, J
AU - Pedersen, F K
AU - Svejgaard, A
N1 - Keywords: Adolescent; Adult; Arthritis, Juvenile Rheumatoid; Child; Child, Preschool; Concanavalin A; Dose-Response Relationship, Immunologic; Female; Genes, MHC Class II; HLA Antigens; HLA-B Antigens; HLA-C Antigens; HLA-DR Antigens; Humans; Lymphocyte Activation; Lymphocyte Culture Test, Mixed; Male; Middle Aged; Phytohemagglutinins; T-Lymphocytes, Regulatory
PY - 1982
Y1 - 1982
N2 - Concanavalin-A-induced suppressor cell activity was investigated in 63 patients with a definite diagnosis of juvenile rheumatoid arthritis. Peripheral blood lymphoid cells from these patients did not have the same ability as cells from normal individuals to suppress the proliferative response of autologous cells, responding to phytohaemaglutinin, Candida albicans antigen, or allogeneic cells. No correlation was found between suppressor activity, disease activity, or number of joints involved. Nor was there any significant association between decreased suppressor cell activity and HLA-A, -B, -C, -D antigens, although there was a tendency towards association between decreased suppressor cell activity and HLA-B27.
AB - Concanavalin-A-induced suppressor cell activity was investigated in 63 patients with a definite diagnosis of juvenile rheumatoid arthritis. Peripheral blood lymphoid cells from these patients did not have the same ability as cells from normal individuals to suppress the proliferative response of autologous cells, responding to phytohaemaglutinin, Candida albicans antigen, or allogeneic cells. No correlation was found between suppressor activity, disease activity, or number of joints involved. Nor was there any significant association between decreased suppressor cell activity and HLA-A, -B, -C, -D antigens, although there was a tendency towards association between decreased suppressor cell activity and HLA-B27.
M3 - Journal article
C2 - 6217541
VL - 16
SP - 361
EP - 367
JO - Scandinavian Journal of Immunology, Supplement
JF - Scandinavian Journal of Immunology, Supplement
SN - 0301-6323
IS - 5
ER -
ID: 18693188