Complement and immunoglobulin studies in 15 cases of chronic meningococcemia: Properdin deficiency and hypoimmunoglobulinemia
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Complement and immunoglobulin studies in 15 cases of chronic meningococcemia : Properdin deficiency and hypoimmunoglobulinemia. / Nielsen, Hans Erik; Koch, Claus; Mansa, Bendt; Magnussen, Pascal; Bergmann, Olav J.
In: Scandinavian Journal of Infectious Diseases, Vol. 22, No. 1, 01.01.1990, p. 31-36.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Complement and immunoglobulin studies in 15 cases of chronic meningococcemia
T2 - Properdin deficiency and hypoimmunoglobulinemia
AU - Nielsen, Hans Erik
AU - Koch, Claus
AU - Mansa, Bendt
AU - Magnussen, Pascal
AU - Bergmann, Olav J.
PY - 1990/1/1
Y1 - 1990/1/1
N2 - The purpose of this study was to investigate whether patients with chronic meningococcemia have abnormalities in their humoral immune system. The alternative and classical complement system, the levels of IgA, IgG and IgM, as well as IgG subclasses were studied in 15 individuals who had recovered from chronic meningococcemia. We found one individual with complete deficiency of properdin, a component of the alternative complement pathway. In the other patients, the complement system was normal. The mean plasma IgG concentration was significantly below normal in the patient group, while the mean values of IgA, IgM and the IgG subclasses were normal. Two individuals, however, had low IgG2 and IgG4 levels. We conclude that properdin deficiency and reduced plasma IgG levels may predispose to chronic meningococcal disease, but that the majority of patients with chronic meningococcemia have a normal humoral immune system.
AB - The purpose of this study was to investigate whether patients with chronic meningococcemia have abnormalities in their humoral immune system. The alternative and classical complement system, the levels of IgA, IgG and IgM, as well as IgG subclasses were studied in 15 individuals who had recovered from chronic meningococcemia. We found one individual with complete deficiency of properdin, a component of the alternative complement pathway. In the other patients, the complement system was normal. The mean plasma IgG concentration was significantly below normal in the patient group, while the mean values of IgA, IgM and the IgG subclasses were normal. Two individuals, however, had low IgG2 and IgG4 levels. We conclude that properdin deficiency and reduced plasma IgG levels may predispose to chronic meningococcal disease, but that the majority of patients with chronic meningococcemia have a normal humoral immune system.
UR - http://www.scopus.com/inward/record.url?scp=0025056808&partnerID=8YFLogxK
U2 - 10.3109/00365549009023116
DO - 10.3109/00365549009023116
M3 - Journal article
C2 - 2320962
AN - SCOPUS:0025056808
VL - 22
SP - 31
EP - 36
JO - Scandinavian Journal of Infectious Diseases, Supplement
JF - Scandinavian Journal of Infectious Diseases, Supplement
SN - 0300-8878
IS - 1
ER -
ID: 224709706