Comparison of Global Cerebral Blood Flow Measured by Phase-Contrast Mapping MRI with O-15-H2O Positron Emission Tomography
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Comparison of Global Cerebral Blood Flow Measured by Phase-Contrast Mapping MRI with O-15-H2O Positron Emission Tomography. / Vestergaard, Mark Bitsch; Lindberg, Ulrich; Aachmann-Andersen, Niels Jacob; Lisbjerg, Kristian; Christensen, Soren Just; Rasmussen, Peter; Olsen, Niels Vidiendal; Law, Ian; Larsson, Henrik Bo Wiberg; Henriksen, Otto Molby.
In: Journal of Magnetic Resonance Imaging, Vol. 45, No. 3, 2017, p. 692-699.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Comparison of Global Cerebral Blood Flow Measured by Phase-Contrast Mapping MRI with O-15-H2O Positron Emission Tomography
AU - Vestergaard, Mark Bitsch
AU - Lindberg, Ulrich
AU - Aachmann-Andersen, Niels Jacob
AU - Lisbjerg, Kristian
AU - Christensen, Soren Just
AU - Rasmussen, Peter
AU - Olsen, Niels Vidiendal
AU - Law, Ian
AU - Larsson, Henrik Bo Wiberg
AU - Henriksen, Otto Molby
PY - 2017
Y1 - 2017
N2 - PurposeTo compare mean global cerebral blood flow (CBF) measured by phase-contrast mapping magnetic resonance imaging (PCM MRI) and by 15O-H2O positron emission tomography (PET) in healthy subjects. PCM MRI is increasingly being used to measure mean global CBF, but has not been validated in vivo against an accepted reference technique.Materials and MethodsSame-day measurements of CBF by 15O-H2O PET and subsequently by PCM MRI were performed on 22 healthy young male volunteers. Global CBF by PET was determined by applying a one-tissue compartment model with measurement of the arterial input function. Flow was measured in the internal carotid and vertebral arteries by a noncardiac triggered PCM MRI sequence at 3T. The measured flow was normalized to total brain weight determined from a volume-segmented 3D T1-weighted anatomical MR-scan.ResultsMean CBF was 34.9 ± 3.4 mL/100 g/min measured by 15O-H2O PET and 57.0 ± 6.8 mL/100 g/min measured by PCM MRI. The measurements were highly correlated (P = 0.0008, R2 = 0.44), although values obtained by PCM MRI were higher compared to 15O-H2O PET (absolute and relative differences were 22.0 ± 5.2 mL/100 g/min and 63.4 ± 14.8%, respectively).ConclusionThis study confirms the use of PCM MRI for quantification of global CBF, but also that PCM MRI systematically yields higher values relative to 15O-H2O PET, probably related to methodological bias.
AB - PurposeTo compare mean global cerebral blood flow (CBF) measured by phase-contrast mapping magnetic resonance imaging (PCM MRI) and by 15O-H2O positron emission tomography (PET) in healthy subjects. PCM MRI is increasingly being used to measure mean global CBF, but has not been validated in vivo against an accepted reference technique.Materials and MethodsSame-day measurements of CBF by 15O-H2O PET and subsequently by PCM MRI were performed on 22 healthy young male volunteers. Global CBF by PET was determined by applying a one-tissue compartment model with measurement of the arterial input function. Flow was measured in the internal carotid and vertebral arteries by a noncardiac triggered PCM MRI sequence at 3T. The measured flow was normalized to total brain weight determined from a volume-segmented 3D T1-weighted anatomical MR-scan.ResultsMean CBF was 34.9 ± 3.4 mL/100 g/min measured by 15O-H2O PET and 57.0 ± 6.8 mL/100 g/min measured by PCM MRI. The measurements were highly correlated (P = 0.0008, R2 = 0.44), although values obtained by PCM MRI were higher compared to 15O-H2O PET (absolute and relative differences were 22.0 ± 5.2 mL/100 g/min and 63.4 ± 14.8%, respectively).ConclusionThis study confirms the use of PCM MRI for quantification of global CBF, but also that PCM MRI systematically yields higher values relative to 15O-H2O PET, probably related to methodological bias.
KW - cerebral blood flow
KW - phase-contrast mapping
KW - positron emission tomography
U2 - 10.1002/jmri.25442
DO - 10.1002/jmri.25442
M3 - Journal article
C2 - 27619317
VL - 45
SP - 692
EP - 699
JO - Journal of Magnetic Resonance Imaging
JF - Journal of Magnetic Resonance Imaging
SN - 1053-1807
IS - 3
ER -
ID: 182583585