Comparing the responses of the UK, Sweden and Denmark to COVID-19 using counterfactual modelling
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Comparing the responses of the UK, Sweden and Denmark to COVID-19 using counterfactual modelling. / Mishra, Swapnil; Scott, James A.; Laydon, Daniel J.; Flaxman, Seth; Gandy, Axel; Mellan, Thomas A.; Unwin, H. Juliette T.; Vollmer, Michaela; Coupland, Helen; Ratmann, Oliver; Monod, Melodie; Zhu, Harrison H.; Cori, Anne; Gaythorpe, Katy A.M.; Whittles, Lilith K.; Whittaker, Charles; Donnelly, Christl A.; Ferguson, Neil M.; Bhatt, Samir.
In: Scientific Reports, Vol. 11, No. 1, 16342, 2021.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Comparing the responses of the UK, Sweden and Denmark to COVID-19 using counterfactual modelling
AU - Mishra, Swapnil
AU - Scott, James A.
AU - Laydon, Daniel J.
AU - Flaxman, Seth
AU - Gandy, Axel
AU - Mellan, Thomas A.
AU - Unwin, H. Juliette T.
AU - Vollmer, Michaela
AU - Coupland, Helen
AU - Ratmann, Oliver
AU - Monod, Melodie
AU - Zhu, Harrison H.
AU - Cori, Anne
AU - Gaythorpe, Katy A.M.
AU - Whittles, Lilith K.
AU - Whittaker, Charles
AU - Donnelly, Christl A.
AU - Ferguson, Neil M.
AU - Bhatt, Samir
N1 - Publisher Copyright: © 2021, The Author(s).
PY - 2021
Y1 - 2021
N2 - The UK and Sweden have among the worst per-capita COVID-19 mortality in Europe. Sweden stands out for its greater reliance on voluntary, rather than mandatory, control measures. We explore how the timing and effectiveness of control measures in the UK, Sweden and Denmark shaped COVID-19 mortality in each country, using a counterfactual assessment: what would the impact have been, had each country adopted the others’ policies? Using a Bayesian semi-mechanistic model without prior assumptions on the mechanism or effectiveness of interventions, we estimate the time-varying reproduction number for the UK, Sweden and Denmark from daily mortality data. We use two approaches to evaluate counterfactuals which transpose the transmission profile from one country onto another, in each country’s first wave from 13th March (when stringent interventions began) until 1st July 2020. UK mortality would have approximately doubled had Swedish policy been adopted, while Swedish mortality would have more than halved had Sweden adopted UK or Danish strategies. Danish policies were most effective, although differences between the UK and Denmark were significant for one counterfactual approach only. Our analysis shows that small changes in the timing or effectiveness of interventions have disproportionately large effects on total mortality within a rapidly growing epidemic.
AB - The UK and Sweden have among the worst per-capita COVID-19 mortality in Europe. Sweden stands out for its greater reliance on voluntary, rather than mandatory, control measures. We explore how the timing and effectiveness of control measures in the UK, Sweden and Denmark shaped COVID-19 mortality in each country, using a counterfactual assessment: what would the impact have been, had each country adopted the others’ policies? Using a Bayesian semi-mechanistic model without prior assumptions on the mechanism or effectiveness of interventions, we estimate the time-varying reproduction number for the UK, Sweden and Denmark from daily mortality data. We use two approaches to evaluate counterfactuals which transpose the transmission profile from one country onto another, in each country’s first wave from 13th March (when stringent interventions began) until 1st July 2020. UK mortality would have approximately doubled had Swedish policy been adopted, while Swedish mortality would have more than halved had Sweden adopted UK or Danish strategies. Danish policies were most effective, although differences between the UK and Denmark were significant for one counterfactual approach only. Our analysis shows that small changes in the timing or effectiveness of interventions have disproportionately large effects on total mortality within a rapidly growing epidemic.
U2 - 10.1038/s41598-021-95699-9
DO - 10.1038/s41598-021-95699-9
M3 - Journal article
C2 - 34381102
AN - SCOPUS:85112297294
VL - 11
JO - Scientific Reports
JF - Scientific Reports
SN - 2045-2322
IS - 1
M1 - 16342
ER -
ID: 290663250