Comparative review of the nasal carriage and genetic characteristics of Staphylococcus aureus in healthy livestock: Insight into zoonotic and anthroponotic clones
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Comparative review of the nasal carriage and genetic characteristics of Staphylococcus aureus in healthy livestock : Insight into zoonotic and anthroponotic clones. / Abdullahi, Idris Nasir; Lozano, Carmen; Saidenberg, Andre Becker Simoes; Latorre-Fernández, Javier; Zarazaga, Myriam; Torres, Carmen.
In: Infection, Genetics and Evolution, Vol. 109, 105408, 2023.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Comparative review of the nasal carriage and genetic characteristics of Staphylococcus aureus in healthy livestock
T2 - Insight into zoonotic and anthroponotic clones
AU - Abdullahi, Idris Nasir
AU - Lozano, Carmen
AU - Saidenberg, Andre Becker Simoes
AU - Latorre-Fernández, Javier
AU - Zarazaga, Myriam
AU - Torres, Carmen
N1 - Publisher Copyright: © 2023 The Authors
PY - 2023
Y1 - 2023
N2 - Given the central role of livestock in understanding the genomic epidemiology of S. aureus, the present study systematically reviewed and synthesized data on the nasal S. aureus carriage, resistance patterns to critical antimicrobial agents, virulence factors and genetic lineages among healthy livestock. Bibliographical databases were searched for published studies from May 2003 to May 2022 on nasal S. aureus carriage, their phenotypic and genetic characteristics among healthy pigs (A), sheep and goats (B), cattle (C), poultry (D), camels (E) and buffaloes (F). Special focus was given to the prevalence of nasal MRSA, MRSA-CC398, MRSA-CC9, mecC-MRSA, MSSA-CC398, and resistance to linezolid (LZDR), chloramphenicol (CLOR) and tetracycline (TETR) in S. aureus isolates. Of the 5492 studies identified, 146 comprised groups A(83)/B(18)/C(33)/D(4)/E(5)/F(3), and were found eligible. The overall pooled nasal prevalence of MRSA in healthy livestock was 13.8% (95% CI: 13.5–14.1) among a pooled 48,154 livestock population. Specifically, the pooled prevalence in groups A to F were: 16.0% (95% CI: 15.6–16.4), 3.7% (95% CI: 2.9–4.6), 13.6% (95% CI: 12.8–14.4), 5.8% (95% CI: 5.1–6.5), 7.1% (95% CI: 6.1–10.7), and 2.8% (95% CI: 1.5–4.8), respectively. These values varied considerably by continent. Varied pooled prevalences of CC398 lineage with respect to MRSA isolates were obtained, with the highest from pigs and cattle (>70%). Moreover, other classical animal-adapted MRSA as well as MSSA-CC398-t1928 were reported. TETR-MSSA was lowest in cattle (18.9%) and highest in pigs (80.7%). LZDR-S. aureus was reported in 8 studies (mediated by optrA and cfr), mainly in pigs (n = 4), while CLOR-S. aureus was reported in 32 studies. The virulence genes luk-S/F-PV, tst, etd, sea, see were sparsely reported, and only in non-CC398-MRSA lineages. Certain S. aureus clones and critical AMR appeared to have predominance in some livestock, as in the case of pigs that are high nasal carriers of MRSA-CC398 and -CC9, and MSSA-CC398. These findings highlight the need for adequate prevention against the transmission of zoonotic S. aureus lineages to humans.
AB - Given the central role of livestock in understanding the genomic epidemiology of S. aureus, the present study systematically reviewed and synthesized data on the nasal S. aureus carriage, resistance patterns to critical antimicrobial agents, virulence factors and genetic lineages among healthy livestock. Bibliographical databases were searched for published studies from May 2003 to May 2022 on nasal S. aureus carriage, their phenotypic and genetic characteristics among healthy pigs (A), sheep and goats (B), cattle (C), poultry (D), camels (E) and buffaloes (F). Special focus was given to the prevalence of nasal MRSA, MRSA-CC398, MRSA-CC9, mecC-MRSA, MSSA-CC398, and resistance to linezolid (LZDR), chloramphenicol (CLOR) and tetracycline (TETR) in S. aureus isolates. Of the 5492 studies identified, 146 comprised groups A(83)/B(18)/C(33)/D(4)/E(5)/F(3), and were found eligible. The overall pooled nasal prevalence of MRSA in healthy livestock was 13.8% (95% CI: 13.5–14.1) among a pooled 48,154 livestock population. Specifically, the pooled prevalence in groups A to F were: 16.0% (95% CI: 15.6–16.4), 3.7% (95% CI: 2.9–4.6), 13.6% (95% CI: 12.8–14.4), 5.8% (95% CI: 5.1–6.5), 7.1% (95% CI: 6.1–10.7), and 2.8% (95% CI: 1.5–4.8), respectively. These values varied considerably by continent. Varied pooled prevalences of CC398 lineage with respect to MRSA isolates were obtained, with the highest from pigs and cattle (>70%). Moreover, other classical animal-adapted MRSA as well as MSSA-CC398-t1928 were reported. TETR-MSSA was lowest in cattle (18.9%) and highest in pigs (80.7%). LZDR-S. aureus was reported in 8 studies (mediated by optrA and cfr), mainly in pigs (n = 4), while CLOR-S. aureus was reported in 32 studies. The virulence genes luk-S/F-PV, tst, etd, sea, see were sparsely reported, and only in non-CC398-MRSA lineages. Certain S. aureus clones and critical AMR appeared to have predominance in some livestock, as in the case of pigs that are high nasal carriers of MRSA-CC398 and -CC9, and MSSA-CC398. These findings highlight the need for adequate prevention against the transmission of zoonotic S. aureus lineages to humans.
KW - Antimicrobial resistance
KW - LA-MRSA
KW - Linezolid-resistant staphylococci
KW - livestock
KW - MRSA-CC398
KW - MRSA-CC9
KW - MSSA-CC398
KW - Nasal staphylococci
KW - Staphylococcal zoonosis
U2 - 10.1016/j.meegid.2023.105408
DO - 10.1016/j.meegid.2023.105408
M3 - Review
C2 - 36773670
AN - SCOPUS:85148771476
VL - 109
JO - Infection, Genetics and Evolution
JF - Infection, Genetics and Evolution
SN - 1567-1348
M1 - 105408
ER -
ID: 340118566