Comparative analysis of the molecular mechanisms of recombination in hepatitis C virus
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Comparative analysis of the molecular mechanisms of recombination in hepatitis C virus. / Galli, Andrea; Bukh, Jens.
In: Trends in Microbiology, Vol. 22, No. 6, 06.2014, p. 354-64.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Comparative analysis of the molecular mechanisms of recombination in hepatitis C virus
AU - Galli, Andrea
AU - Bukh, Jens
N1 - Copyright © 2014 Elsevier Ltd. All rights reserved.
PY - 2014/6
Y1 - 2014/6
N2 - Genetic recombination is an important evolutionary mechanism for RNA viruses. The significance of this phenomenon for hepatitis C virus (HCV) has recently become evident, with the identification of circulating recombinant forms in HCV-infected individuals and by novel data from studies permitted by advances in HCV cell culture systems and genotyping protocols. HCV is readily able to produce viable recombinants, using replicative and non-replicative molecular mechanisms. However, our knowledge of the required molecular mechanisms remains limited. Understanding how HCV recombines might be instrumental for a better monitoring of global epidemiology, to clarify the virus evolution, and evaluate the impact of recombinant forms on the efficacy of oncoming combination drug therapies. For the latter, frequency and location of recombination events could affect the efficacy of multidrug regimens. This review will focus on current data available on HCV recombination, also in relation to more detailed data from other RNA viruses.
AB - Genetic recombination is an important evolutionary mechanism for RNA viruses. The significance of this phenomenon for hepatitis C virus (HCV) has recently become evident, with the identification of circulating recombinant forms in HCV-infected individuals and by novel data from studies permitted by advances in HCV cell culture systems and genotyping protocols. HCV is readily able to produce viable recombinants, using replicative and non-replicative molecular mechanisms. However, our knowledge of the required molecular mechanisms remains limited. Understanding how HCV recombines might be instrumental for a better monitoring of global epidemiology, to clarify the virus evolution, and evaluate the impact of recombinant forms on the efficacy of oncoming combination drug therapies. For the latter, frequency and location of recombination events could affect the efficacy of multidrug regimens. This review will focus on current data available on HCV recombination, also in relation to more detailed data from other RNA viruses.
KW - Evolution, Molecular
KW - Hepacivirus
KW - Models, Genetic
KW - Recombination, Genetic
KW - Virus Replication
U2 - 10.1016/j.tim.2014.02.005
DO - 10.1016/j.tim.2014.02.005
M3 - Journal article
C2 - 24636243
VL - 22
SP - 354
EP - 364
JO - Trends in Microbiology
JF - Trends in Microbiology
SN - 0966-842X
IS - 6
ER -
ID: 131071375