Cognitive Function 3 and 12 Months After ICU Discharge: A Prospective Cohort Study
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Cognitive Function 3 and 12 Months After ICU Discharge : A Prospective Cohort Study. / Estrup, Stine; Kjer, Cilia K W; Vilhelmsen, Frederik; Poulsen, Lone M; Gøgenur, Ismail; Mathiesen, Ole.
In: Critical Care Medicine, Vol. 46, No. 12, 2018, p. e1121-e1127.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Cognitive Function 3 and 12 Months After ICU Discharge
T2 - A Prospective Cohort Study
AU - Estrup, Stine
AU - Kjer, Cilia K W
AU - Vilhelmsen, Frederik
AU - Poulsen, Lone M
AU - Gøgenur, Ismail
AU - Mathiesen, Ole
PY - 2018
Y1 - 2018
N2 - OBJECTIVES: Studies have shown impaired cognitive function after ICU discharge. We aimed to describe long-term cognitive function in Danish ICU patients.DESIGN: Prospective cohort study.SETTING: Single-center ICU at Zealand University Hospital, Køge, Denmark.PATIENTS: Adult patients admitted for over 24 hours.INTERVENTION: Three and 12 months after discharge, the patients were visited at home and tested with the Repeatable Battery for the Assessment of Neuropsychological Status.MEASUREMENTS AND MAIN RESULTS: We included 161 patients, 79 patients had a 3-month and 53 a 12-month follow-up visit. The primary reasons for not being visited at 3-month were death (44 patients), decline (26 patients), or transferal to another ICU (6 patients). Visited patients were median 67 years old (interquartile range, 59-73), had a median Acute Physiology and Chronic Health Evaluation score of 20 (interquartile range, 16-26), 58% were on a ventilator, and 30% were surgical patients. The mean Repeatable Battery for the Assessment of Neuropsychological Status score was 67 (SD, 21), compared with a normal value of 100 (15). A total of 57% had Repeatable Battery for the Assessment of Neuropsychological Status scores corresponding to moderate traumatic brain injury, 46% scored corresponding to light Alzheimer's disease, and 73% corresponding to mild cognitive impairment. After 12 months, the Repeatable Battery for the Assessment of Neuropsychological Status was still reduced (71 [25]). We examined protective and risk factors using multiple linear regression and found protective effects of being employed before admission (p = 0.0005) or being admitted from a surgical ward (p = 0.019).CONCLUSIONS: In this prospective cohort study of Danish ICU patients, we found significantly reduced cognitive function for intensive care patients 3 and 12 months after discharge.
AB - OBJECTIVES: Studies have shown impaired cognitive function after ICU discharge. We aimed to describe long-term cognitive function in Danish ICU patients.DESIGN: Prospective cohort study.SETTING: Single-center ICU at Zealand University Hospital, Køge, Denmark.PATIENTS: Adult patients admitted for over 24 hours.INTERVENTION: Three and 12 months after discharge, the patients were visited at home and tested with the Repeatable Battery for the Assessment of Neuropsychological Status.MEASUREMENTS AND MAIN RESULTS: We included 161 patients, 79 patients had a 3-month and 53 a 12-month follow-up visit. The primary reasons for not being visited at 3-month were death (44 patients), decline (26 patients), or transferal to another ICU (6 patients). Visited patients were median 67 years old (interquartile range, 59-73), had a median Acute Physiology and Chronic Health Evaluation score of 20 (interquartile range, 16-26), 58% were on a ventilator, and 30% were surgical patients. The mean Repeatable Battery for the Assessment of Neuropsychological Status score was 67 (SD, 21), compared with a normal value of 100 (15). A total of 57% had Repeatable Battery for the Assessment of Neuropsychological Status scores corresponding to moderate traumatic brain injury, 46% scored corresponding to light Alzheimer's disease, and 73% corresponding to mild cognitive impairment. After 12 months, the Repeatable Battery for the Assessment of Neuropsychological Status was still reduced (71 [25]). We examined protective and risk factors using multiple linear regression and found protective effects of being employed before admission (p = 0.0005) or being admitted from a surgical ward (p = 0.019).CONCLUSIONS: In this prospective cohort study of Danish ICU patients, we found significantly reduced cognitive function for intensive care patients 3 and 12 months after discharge.
U2 - 10.1097/CCM.0000000000003391
DO - 10.1097/CCM.0000000000003391
M3 - Journal article
C2 - 30188383
VL - 46
SP - e1121-e1127
JO - New Horizons: Science and Practice of Acute Medicine
JF - New Horizons: Science and Practice of Acute Medicine
SN - 1063-7389
IS - 12
ER -
ID: 222106109