Coeliac disease in children: a social epidemiological study in Sweden
Research output: Contribution to journal › Journal article › Research › peer-review
AIM: Little is known on the possible existence of socioeconomic and geographical differences in early coeliac disease (CD) risk. Therefore, we investigated these aspects in children before age two.
METHODS: Linking the Swedish Medical Birth Registry to several other national registries, we identified all singletons born in Sweden from 1987 to 1993 (n = 792,401) and followed them until 2 years of age to identify cases of CD. Applying multilevel logistic regression analysis, we investigated the association between socioeconomic position (SEP) and CD in children and also whether a possible geographical variation in CD risk was explained by individual characteristics.
RESULTS: Low SEP was associated with CD in boys OR 1.37 (95% CI 1.03-1.82), but not in girls OR 0.87 (95% CI 0.68-1.12). We found a considerable geographical variation in disease risk (i.e. intra-municipality correlation ≈ 10%) that was not explained by individual characteristics.
CONCLUSIONS: Low SEP is associated with CD in boys but not in girls. Also, CD appears to be conditioned by geographical area of residence. While our study represents an innovative contribution to the epidemiology of CD in children, the reasons for the observed geographical and socioeconomic differences could be speculated but are still unknown.
Original language | English |
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Journal | Acta paediatrica (Oslo, Norway : 1992) |
Volume | 101 |
Issue number | 2 |
Pages (from-to) | 185-91 |
Number of pages | 7 |
ISSN | 0803-5253 |
DOIs | |
Publication status | Published - Feb 2012 |
Externally published | Yes |
Bibliographical note
© 2011 The Author(s)/Acta Paediatrica © 2011 Foundation Acta Paediatrica.
- Celiac Disease/epidemiology, Child, Preschool, Data Collection, Female, Humans, Infant, Male, Prospective Studies, Registries, Residence Characteristics/statistics & numerical data, Risk Factors, Sex Distribution, Social Class, Sweden/epidemiology
Research areas
ID: 365307260