Clinicopathologic factors identify sporadic mismatch repair-defective colon cancers.

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Clinicopathologic factors identify sporadic mismatch repair-defective colon cancers. / Halvarsson, Britta; Anderson, Harald; Domanska, Katarina; Lindmark, Gudrun; Nilbert, Mef.

In: American Journal of Clinical Pathology, Vol. 129, No. 2, 2008, p. 238-44.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Halvarsson, B, Anderson, H, Domanska, K, Lindmark, G & Nilbert, M 2008, 'Clinicopathologic factors identify sporadic mismatch repair-defective colon cancers.', American Journal of Clinical Pathology, vol. 129, no. 2, pp. 238-44. https://doi.org/10.1309/0PP5GDRTXUDVKAWJ

APA

Halvarsson, B., Anderson, H., Domanska, K., Lindmark, G., & Nilbert, M. (2008). Clinicopathologic factors identify sporadic mismatch repair-defective colon cancers. American Journal of Clinical Pathology, 129(2), 238-44. https://doi.org/10.1309/0PP5GDRTXUDVKAWJ

Vancouver

Halvarsson B, Anderson H, Domanska K, Lindmark G, Nilbert M. Clinicopathologic factors identify sporadic mismatch repair-defective colon cancers. American Journal of Clinical Pathology. 2008;129(2):238-44. https://doi.org/10.1309/0PP5GDRTXUDVKAWJ

Author

Halvarsson, Britta ; Anderson, Harald ; Domanska, Katarina ; Lindmark, Gudrun ; Nilbert, Mef. / Clinicopathologic factors identify sporadic mismatch repair-defective colon cancers. In: American Journal of Clinical Pathology. 2008 ; Vol. 129, No. 2. pp. 238-44.

Bibtex

@article{e6581bb9145e4ebcb2d460fc8355e803,
title = "Clinicopathologic factors identify sporadic mismatch repair-defective colon cancers.",
abstract = "Identification of sporadic mismatch repair (MMR)-defective colon cancers is increasingly demanded for decisions on adjuvant therapies. We evaluated clinicopathologic factors for the identification of these prognostically favorable tumors. Histopathologic features in 238 consecutive colon cancers were linked to MMR status based on immunostaining and BRAF mutation status.MMR defects were identified in 22.7% of the tumors, with 46 classified as sporadic. When the clinical parameters of age, sex, and proximal tumor location were combined with the morphologic features with the highest relative risks (RRs), eg, mucinous differentiation (RR, 9.0), tumor-infiltrating lymphocytes (RR, 7.5), absence of necrosis (RR, 7.5), and expanding growth pattern (RR, 5.0) into a 7-factor index, the presence of at least 4 features identified the MMR-defective tumors with 92.3% sensitivity and 75.3% specificity and excluded 61.5% of the tumors from MMR testing. This clinicopathologic index thus successfully selects MMR-defective colon cancers. Udgivelsesdato: 2008-Feb",
author = "Britta Halvarsson and Harald Anderson and Katarina Domanska and Gudrun Lindmark and Mef Nilbert",
year = "2008",
doi = "http://dx.doi.org/10.1309/0PP5GDRTXUDVKAWJ",
language = "English",
volume = "129",
pages = "238--44",
journal = "American Journal of Clinical Pathology",
issn = "0002-9173",
publisher = "Oxford University Press",
number = "2",

}

RIS

TY - JOUR

T1 - Clinicopathologic factors identify sporadic mismatch repair-defective colon cancers.

AU - Halvarsson, Britta

AU - Anderson, Harald

AU - Domanska, Katarina

AU - Lindmark, Gudrun

AU - Nilbert, Mef

PY - 2008

Y1 - 2008

N2 - Identification of sporadic mismatch repair (MMR)-defective colon cancers is increasingly demanded for decisions on adjuvant therapies. We evaluated clinicopathologic factors for the identification of these prognostically favorable tumors. Histopathologic features in 238 consecutive colon cancers were linked to MMR status based on immunostaining and BRAF mutation status.MMR defects were identified in 22.7% of the tumors, with 46 classified as sporadic. When the clinical parameters of age, sex, and proximal tumor location were combined with the morphologic features with the highest relative risks (RRs), eg, mucinous differentiation (RR, 9.0), tumor-infiltrating lymphocytes (RR, 7.5), absence of necrosis (RR, 7.5), and expanding growth pattern (RR, 5.0) into a 7-factor index, the presence of at least 4 features identified the MMR-defective tumors with 92.3% sensitivity and 75.3% specificity and excluded 61.5% of the tumors from MMR testing. This clinicopathologic index thus successfully selects MMR-defective colon cancers. Udgivelsesdato: 2008-Feb

AB - Identification of sporadic mismatch repair (MMR)-defective colon cancers is increasingly demanded for decisions on adjuvant therapies. We evaluated clinicopathologic factors for the identification of these prognostically favorable tumors. Histopathologic features in 238 consecutive colon cancers were linked to MMR status based on immunostaining and BRAF mutation status.MMR defects were identified in 22.7% of the tumors, with 46 classified as sporadic. When the clinical parameters of age, sex, and proximal tumor location were combined with the morphologic features with the highest relative risks (RRs), eg, mucinous differentiation (RR, 9.0), tumor-infiltrating lymphocytes (RR, 7.5), absence of necrosis (RR, 7.5), and expanding growth pattern (RR, 5.0) into a 7-factor index, the presence of at least 4 features identified the MMR-defective tumors with 92.3% sensitivity and 75.3% specificity and excluded 61.5% of the tumors from MMR testing. This clinicopathologic index thus successfully selects MMR-defective colon cancers. Udgivelsesdato: 2008-Feb

U2 - http://dx.doi.org/10.1309/0PP5GDRTXUDVKAWJ

DO - http://dx.doi.org/10.1309/0PP5GDRTXUDVKAWJ

M3 - Journal article

VL - 129

SP - 238

EP - 244

JO - American Journal of Clinical Pathology

JF - American Journal of Clinical Pathology

SN - 0002-9173

IS - 2

ER -

ID: 40183297