Clinical translation of pluripotent stem cell-based therapies: successes and challenges
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- dev202067
Final published version, 1.2 MB, PDF document
The translational stem cell research field has progressed immensely in the past decade. Development and refinement of differentiation protocols now allows the generation of a range of cell types, such as pancreatic β-cells and dopaminergic neurons, from human pluripotent stem cells (hPSCs) in an efficient and good manufacturing practice-compliant fashion. This has led to the initiation of several clinical trials using hPSC-derived cells to replace lost or dysfunctional cells, demonstrating evidence of both safety and efficacy. Here, we highlight successes from some of the hPSC-based trials reporting early signs of efficacy and discuss common challenges in clinical translation of cell therapies.
Original language | English |
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Article number | dev202067 |
Journal | Development (Cambridge, England) |
Volume | 151 |
Issue number | 7 |
Number of pages | 9 |
ISSN | 0950-1991 |
DOIs | |
Publication status | Published - 2024 |
Bibliographical note
© 2024. Published by The Company of Biologists Ltd.
- Humans, Pluripotent Stem Cells, Cell Line, Cell Differentiation, Cell- and Tissue-Based Therapy, Stem Cell Research
Research areas
ID: 390195880