Clinical outcomes in clinical trials of anti-HIV treatment

Research output: Contribution to journal › Journal article › Research › peer-review

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Clinical outcomes in clinical trials of anti-HIV treatment. / Reekie, J; Mocroft, A; J, Neaton; Lundgren, Jens Dilling.

In: Future HIV Ther, Vol. 1, No. 3, 2007, p. 251-8.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Reekie, J, Mocroft, A, J, N & Lundgren, JD 2007, 'Clinical outcomes in clinical trials of anti-HIV treatment', Future HIV Ther, vol. 1, no. 3, pp. 251-8. https://doi.org/10.2217/17469600.1.3.251

APA

Reekie, J., Mocroft, A., J, N., & Lundgren, J. D. (2007). Clinical outcomes in clinical trials of anti-HIV treatment. Future HIV Ther, 1(3), 251-8. https://doi.org/10.2217/17469600.1.3.251

Vancouver

Reekie J, Mocroft A, J N, Lundgren JD. Clinical outcomes in clinical trials of anti-HIV treatment. Future HIV Ther. 2007;1(3):251-8. https://doi.org/10.2217/17469600.1.3.251

Author

Reekie, J ; Mocroft, A ; J, Neaton ; Lundgren, Jens Dilling. / Clinical outcomes in clinical trials of anti-HIV treatment. In: Future HIV Ther. 2007 ; Vol. 1, No. 3. pp. 251-8.

Bibtex

@article{66d11e1656624f68ba7fdfc5b3fd17b0,
title = "Clinical outcomes in clinical trials of anti-HIV treatment",
abstract = "Since the introduction of combination antiretroviral therapy, there has been a decrease in both AIDS-defining illnesses and deaths. This decrease meant that performing clinical trials with clinical outcomes in HIV infection became more time consuming and hence costly. Improved understanding and knowledge of HIV led to short-term trials using surrogate outcomes such as viral load and CD4 count. This established a faster drug approval process that complimented the rapid need to evaluate and provide access to drugs based on short-term trials. However, no treatment has yet been found that eradicates the infection, so when treatment is started it is currently a lifelong commitment. Is it reasonable then that guidelines are based almost completely on short-term randomized trials and observational studies of surrogate markers, or is there still a need for trials with clinical outcomes?",
author = "J Reekie and A Mocroft and Neaton J and Lundgren, {Jens Dilling}",
year = "2007",
doi = "http://dx.doi.org/10.2217/17469600.1.3.251",
language = "English",
volume = "1",
pages = "251--8",
journal = "Future HIV Ther",
number = "3",

}

RIS

TY - JOUR

T1 - Clinical outcomes in clinical trials of anti-HIV treatment

AU - Reekie, J

AU - Mocroft, A

AU - J, Neaton

AU - Lundgren, Jens Dilling

PY - 2007

Y1 - 2007

N2 - Since the introduction of combination antiretroviral therapy, there has been a decrease in both AIDS-defining illnesses and deaths. This decrease meant that performing clinical trials with clinical outcomes in HIV infection became more time consuming and hence costly. Improved understanding and knowledge of HIV led to short-term trials using surrogate outcomes such as viral load and CD4 count. This established a faster drug approval process that complimented the rapid need to evaluate and provide access to drugs based on short-term trials. However, no treatment has yet been found that eradicates the infection, so when treatment is started it is currently a lifelong commitment. Is it reasonable then that guidelines are based almost completely on short-term randomized trials and observational studies of surrogate markers, or is there still a need for trials with clinical outcomes?

AB - Since the introduction of combination antiretroviral therapy, there has been a decrease in both AIDS-defining illnesses and deaths. This decrease meant that performing clinical trials with clinical outcomes in HIV infection became more time consuming and hence costly. Improved understanding and knowledge of HIV led to short-term trials using surrogate outcomes such as viral load and CD4 count. This established a faster drug approval process that complimented the rapid need to evaluate and provide access to drugs based on short-term trials. However, no treatment has yet been found that eradicates the infection, so when treatment is started it is currently a lifelong commitment. Is it reasonable then that guidelines are based almost completely on short-term randomized trials and observational studies of surrogate markers, or is there still a need for trials with clinical outcomes?

U2 - http://dx.doi.org/10.2217/17469600.1.3.251

DO - http://dx.doi.org/10.2217/17469600.1.3.251

M3 - Journal article

VL - 1

SP - 251

EP - 258

JO - Future HIV Ther

JF - Future HIV Ther

IS - 3

ER -

ID: 40215179