Chronic sleep fragmentation impairs brain interstitial clearance in young wildtype mice
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Chronic sleep fragmentation impairs brain interstitial clearance in young wildtype mice. / Deng, Saiyue; Hu, Yusi; Chen, Simiao; Xue, Yang; Yao, Di; Sun, Qian; Nedergaard, Maiken; Wang, Wei; Ding, Fengfei.
In: Journal of Cerebral Blood Flow and Metabolism, 2024.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Chronic sleep fragmentation impairs brain interstitial clearance in young wildtype mice
AU - Deng, Saiyue
AU - Hu, Yusi
AU - Chen, Simiao
AU - Xue, Yang
AU - Yao, Di
AU - Sun, Qian
AU - Nedergaard, Maiken
AU - Wang, Wei
AU - Ding, Fengfei
N1 - Publisher Copyright: © The Author(s) 2024.
PY - 2024
Y1 - 2024
N2 - Accumulating evidence shows that most chronic neurological diseases have a link with sleep disturbances, and that patients with chronically poor sleep undergo an accelerated cognitive decline. Indeed, a single-night of sleep deprivation may increase metabolic waste levels in cerebrospinal fluid. However, it remains unknown how chronic sleep disturbances in isolation from an underlying neurological disease may affect the glymphatic system. Clearance of brain interstitial waste by the glymphatic system occurs primarily during sleep, driven by multiple oscillators including arterial pulsatility, and vasomotion. Herein, we induced sleep fragmentation in young wildtype mice and assessed the effects on glymphatic activity and cognitive functions. Chronic sleep fragmentation reduced glymphatic function and impaired cognitive functions in healthy mice. A mechanistic analysis showed that the chronic sleep fragmentation suppressed slow vasomotion, without altering cardiac-driven pulsations. Taken together, results of this study document that chronic sleep fragmentation suppresses brain metabolite clearance and impairs cognition, even in the absence of disease.
AB - Accumulating evidence shows that most chronic neurological diseases have a link with sleep disturbances, and that patients with chronically poor sleep undergo an accelerated cognitive decline. Indeed, a single-night of sleep deprivation may increase metabolic waste levels in cerebrospinal fluid. However, it remains unknown how chronic sleep disturbances in isolation from an underlying neurological disease may affect the glymphatic system. Clearance of brain interstitial waste by the glymphatic system occurs primarily during sleep, driven by multiple oscillators including arterial pulsatility, and vasomotion. Herein, we induced sleep fragmentation in young wildtype mice and assessed the effects on glymphatic activity and cognitive functions. Chronic sleep fragmentation reduced glymphatic function and impaired cognitive functions in healthy mice. A mechanistic analysis showed that the chronic sleep fragmentation suppressed slow vasomotion, without altering cardiac-driven pulsations. Taken together, results of this study document that chronic sleep fragmentation suppresses brain metabolite clearance and impairs cognition, even in the absence of disease.
KW - Glymphatic function
KW - Interstitial clearance
KW - Pulsatility
KW - Sleep fragmentation
KW - Vasomotion
U2 - 10.1177/0271678X241230188
DO - 10.1177/0271678X241230188
M3 - Journal article
C2 - 38639025
AN - SCOPUS:85190821754
JO - Journal of Cerebral Blood Flow and Metabolism
JF - Journal of Cerebral Blood Flow and Metabolism
SN - 0271-678X
ER -
ID: 390594804