Chronic Alcohol Abuse Leads to Low Bone Mass with No General Loss of Bone Structure or Bone Mechanical Strength
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Chronic Alcohol Abuse Leads to Low Bone Mass with No General Loss of Bone Structure or Bone Mechanical Strength. / Ulhøi, Maiken Parm; Meldgaard, Karoline; Steiniche, Torben; Odgaard, Anders; Vesterby, Annie.
In: Journal of Forensic Sciences, Vol. 62, No. 1, 01.2017, p. 131-136.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Chronic Alcohol Abuse Leads to Low Bone Mass with No General Loss of Bone Structure or Bone Mechanical Strength
AU - Ulhøi, Maiken Parm
AU - Meldgaard, Karoline
AU - Steiniche, Torben
AU - Odgaard, Anders
AU - Vesterby, Annie
PY - 2017/1
Y1 - 2017/1
N2 - Chronic alcohol abuse (CAA) has deleterious effects on skeletal health. This study examined the impact of CAA on bone with regard to bone density, structure, and strength. Bone specimens from 42 individuals with CAA and 42 individuals without alcohol abuse were obtained at autopsy. Dual-energy X-ray absorptiometry (DEXA), compression testing, ashing, and bone histomorphometry were performed. Individuals with CAA had significantly lower bone mineral density (BMD) in the femoral neck and significantly lower bone volume demonstrated by thinner trabeculae, decreased extent of osteoid surfaces, and lower mean wall thickness of trabecular osteons compared to individuals without alcohol abuse. No significant difference was found for bone strength and structure. Conclusion: CAA leads to low bone mass due to a decrease in bone formation but with no destruction of bone architecture nor a decrease in bone strength. It is questionable whether this per se increases fracture risk.
AB - Chronic alcohol abuse (CAA) has deleterious effects on skeletal health. This study examined the impact of CAA on bone with regard to bone density, structure, and strength. Bone specimens from 42 individuals with CAA and 42 individuals without alcohol abuse were obtained at autopsy. Dual-energy X-ray absorptiometry (DEXA), compression testing, ashing, and bone histomorphometry were performed. Individuals with CAA had significantly lower bone mineral density (BMD) in the femoral neck and significantly lower bone volume demonstrated by thinner trabeculae, decreased extent of osteoid surfaces, and lower mean wall thickness of trabecular osteons compared to individuals without alcohol abuse. No significant difference was found for bone strength and structure. Conclusion: CAA leads to low bone mass due to a decrease in bone formation but with no destruction of bone architecture nor a decrease in bone strength. It is questionable whether this per se increases fracture risk.
KW - bone histomorphometry
KW - bone strength
KW - bone structure
KW - chronic alcohol abuse
KW - forensic science
KW - fracture risk
KW - osteopenia
KW - skeletal health
U2 - 10.1111/1556-4029.13256
DO - 10.1111/1556-4029.13256
M3 - Journal article
C2 - 27864963
AN - SCOPUS:85006059647
VL - 62
SP - 131
EP - 136
JO - Journal of Forensic Sciences
JF - Journal of Forensic Sciences
SN - 0022-1198
IS - 1
ER -
ID: 188113486