Chromosome-scale haplotype-resolved pangenomics
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Chromosome-scale haplotype-resolved pangenomics. / Garg, Shilpa; Balboa, Renzo; Kuja, Josiah.
In: Trends in Genetics, Vol. 38, No. 11, 2022, p. 1103-1107.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Chromosome-scale haplotype-resolved pangenomics
AU - Garg, Shilpa
AU - Balboa, Renzo
AU - Kuja, Josiah
N1 - Publisher Copyright: © 2022 Elsevier Ltd
PY - 2022
Y1 - 2022
N2 - Complete pangenomics is crucial for understanding genetic diversity and evolution across the tree of life. Chromosome-scale, haplotype-resolved pangenomics allows complex structural variations, long-range interactions, and associated functions to be discerned in species populations. We explore the need for high-resolution pangenomes, discuss computational strategies for their development, and describe applications in biodiversity and human health.
AB - Complete pangenomics is crucial for understanding genetic diversity and evolution across the tree of life. Chromosome-scale, haplotype-resolved pangenomics allows complex structural variations, long-range interactions, and associated functions to be discerned in species populations. We explore the need for high-resolution pangenomes, discuss computational strategies for their development, and describe applications in biodiversity and human health.
KW - chromosome-scale haplotypes
KW - genome evolution
KW - genome informatics
KW - genomic diversity
KW - pangenomics
KW - reference genome
U2 - 10.1016/j.tig.2022.06.011
DO - 10.1016/j.tig.2022.06.011
M3 - Journal article
C2 - 35817620
AN - SCOPUS:85133685396
VL - 38
SP - 1103
EP - 1107
JO - Trends in Genetics
JF - Trends in Genetics
SN - 0168-9525
IS - 11
ER -
ID: 321540902