Chromogranin A in the mammalian heart: Expression without secretion
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Chromogranin A in the mammalian heart : Expression without secretion. / Hansen, Lasse H.; Darkner, Stine; Svendsen, Jesper H.; Henningsen, Kristoffer; Pehrson, Steen; Chen, Xu; Vakhrushev, Sergey Y.; Schjoldager, Katrine T.; Goetze, Jens P.
In: Biomarkers in Medicine, Vol. 11, No. 7, 07.2017, p. 541-545.Research output: Contribution to journal › Letter › Research › peer-review
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TY - JOUR
T1 - Chromogranin A in the mammalian heart
T2 - Expression without secretion
AU - Hansen, Lasse H.
AU - Darkner, Stine
AU - Svendsen, Jesper H.
AU - Henningsen, Kristoffer
AU - Pehrson, Steen
AU - Chen, Xu
AU - Vakhrushev, Sergey Y.
AU - Schjoldager, Katrine T.
AU - Goetze, Jens P.
PY - 2017/7
Y1 - 2017/7
N2 - Aim: To investigate whether chromogranin A (CgA) is secreted from the heart into circulation. Materials & methods: Porcine cardiac tissue was analyzed for the presence of CgA-derived glycopeptides using a global O-glycoproteomic strategy. Blood was sampled from the femoral vein, right atrium, coronary sinus and the left atrium from patients with predominantly atrial disease. The local concentration of proatrial natriuretic peptide and CgA was measured with immunoassays. Results: We identified CgA-derived glycopeptides exclusively in the atrial tissue. Proatrial natriuretic peptide is secreted from the heart (coronary sinus [795 pmol/l] vs left atrium [678 pmol/l]; p < 0.01) whereas no CgA gradient across the heart could be established (p = 0.6366). Conclusion: The cardiac atria express but do not secrete CgA into circulation in patients with atrial disease.
AB - Aim: To investigate whether chromogranin A (CgA) is secreted from the heart into circulation. Materials & methods: Porcine cardiac tissue was analyzed for the presence of CgA-derived glycopeptides using a global O-glycoproteomic strategy. Blood was sampled from the femoral vein, right atrium, coronary sinus and the left atrium from patients with predominantly atrial disease. The local concentration of proatrial natriuretic peptide and CgA was measured with immunoassays. Results: We identified CgA-derived glycopeptides exclusively in the atrial tissue. Proatrial natriuretic peptide is secreted from the heart (coronary sinus [795 pmol/l] vs left atrium [678 pmol/l]; p < 0.01) whereas no CgA gradient across the heart could be established (p = 0.6366). Conclusion: The cardiac atria express but do not secrete CgA into circulation in patients with atrial disease.
KW - atrial fibrillation
KW - atrial natriuretic peptide
KW - chromogranin A
KW - heart
KW - secretion
U2 - 10.2217/bmm-2017-0052
DO - 10.2217/bmm-2017-0052
M3 - Letter
C2 - 28685598
AN - SCOPUS:85024365840
VL - 11
SP - 541
EP - 545
JO - Biomarkers in Medicine
JF - Biomarkers in Medicine
SN - 1752-0363
IS - 7
ER -
ID: 184773107