Chromatin dynamics in genome stability: Roles in suppressing endogenous DNA damage and facilitating DNA repair
Research output: Contribution to journal › Review › Research › peer-review
Documents
- Chromatin Dynamics in Genome Stability: Roles in Suppressing Endogenous DNA Damage and Facilitating DNA Repair
Final published version, 927 KB, PDF document
Genomic DNA is compacted into chromatin through packaging with histone and non-histone proteins. Importantly, DNA accessibility is dynamically regulated to ensure genome stability. This is exemplified in the response to DNA damage where chromatin relaxation near genomic lesions serves to promote access of relevant enzymes to specific DNA regions for signaling and repair. Furthermore, recent data highlight genome maintenance roles of chromatin through the regulation of endogenous DNA-templated processes including transcription and replication. Here, we review research that shows the importance of chromatin structure regulation in maintaining genome integrity by multiple mechanisms including facilitating DNA repair and directly suppressing endogenous DNA damage.
Original language | English |
---|---|
Article number | 1486 |
Journal | International Journal of Molecular Sciences |
Volume | 18 |
Issue number | 7 |
Number of pages | 21 |
ISSN | 1661-6596 |
DOIs | |
Publication status | Published - 10 Jul 2017 |
- Chromatin, DNA damage response, Endogenous DNA damage, Genome maintenance
Research areas
Number of downloads are based on statistics from Google Scholar and www.ku.dk
ID: 185504235