Chimeric antigen receptor-T-cellebehandling
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Chimeric antigen receptor-T-cellebehandling. / Müller, Klaus; Ifversen, Marianne; Kielsen, Katrine; Petersen, Søren Lykke; Met, Özcan; Svane, Inge Marie.
In: Ugeskrift for Laeger, Vol. 181, No. 20A, V05190309, 2019.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Chimeric antigen receptor-T-cellebehandling
AU - Müller, Klaus
AU - Ifversen, Marianne
AU - Kielsen, Katrine
AU - Petersen, Søren Lykke
AU - Met, Özcan
AU - Svane, Inge Marie
PY - 2019
Y1 - 2019
N2 - Although treatment of haematological cancer has improved significantly during the latest decades, the prognosis is poor in case of relapse or refractory disease. This review describes the chimeric antigen receptor (CAR) T-cell therapy, which has emerged as a new promising treatment principle, in which the patient's own T-cells are genetically modified to recognise cancer cells. The possible side effects are usually only transient. A commercial CD19 CAR T-cell product has recently been approved as treatment for acute lympho-blastic leukaemia in children and young adults in Denmark, and a non-commercial CAR T-cell production is being established.
AB - Although treatment of haematological cancer has improved significantly during the latest decades, the prognosis is poor in case of relapse or refractory disease. This review describes the chimeric antigen receptor (CAR) T-cell therapy, which has emerged as a new promising treatment principle, in which the patient's own T-cells are genetically modified to recognise cancer cells. The possible side effects are usually only transient. A commercial CD19 CAR T-cell product has recently been approved as treatment for acute lympho-blastic leukaemia in children and young adults in Denmark, and a non-commercial CAR T-cell production is being established.
M3 - Tidsskriftartikel
C2 - 31610841
VL - 181
JO - Ugeskrift for Laeger
JF - Ugeskrift for Laeger
SN - 0041-5782
IS - 20A
M1 - V05190309
ER -
ID: 238526118