Childhood trauma in children at familial high risk of schizophrenia or bipolar disorder: A longitudinal study. The Danish High Risk and Resilience Study - VIA 7 and VIA 11
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Childhood trauma in children at familial high risk of schizophrenia or bipolar disorder : A longitudinal study. The Danish High Risk and Resilience Study - VIA 7 and VIA 11. / Brandt, Julie Marie; Hemager, Nicoline; Gregersen, Maja; Søndergaard, Anne; Krantz, Mette Falkenberg; Ohland, Jessica; Wilms, Martin; Rohd, Sinnika Birkehoj; Hjorthoj, Carsten; Veddum, Lotte; Knudsen, Christina Bruun; Andreassen, Anna Krogh; Greve, Aja; Spang, Katrine Soborg; Christiani, Camilla Austa; Ellersgaard, Ditte; Burton, Birgitte Klee; Gantriis, Ditte Lou; Bliksted, Vibeke; Mors, Ole; Plessen, Kerstin Jessica; Jepsen, Jens Richardt Mollegaard; Nordentoft, Merete; Thorup, Anne Amalie Elgaard.
In: British Journal of Clinical Psychology, Vol. 61, No. 4, 2022, p. 875-894.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Childhood trauma in children at familial high risk of schizophrenia or bipolar disorder
T2 - A longitudinal study. The Danish High Risk and Resilience Study - VIA 7 and VIA 11
AU - Brandt, Julie Marie
AU - Hemager, Nicoline
AU - Gregersen, Maja
AU - Søndergaard, Anne
AU - Krantz, Mette Falkenberg
AU - Ohland, Jessica
AU - Wilms, Martin
AU - Rohd, Sinnika Birkehoj
AU - Hjorthoj, Carsten
AU - Veddum, Lotte
AU - Knudsen, Christina Bruun
AU - Andreassen, Anna Krogh
AU - Greve, Aja
AU - Spang, Katrine Soborg
AU - Christiani, Camilla Austa
AU - Ellersgaard, Ditte
AU - Burton, Birgitte Klee
AU - Gantriis, Ditte Lou
AU - Bliksted, Vibeke
AU - Mors, Ole
AU - Plessen, Kerstin Jessica
AU - Jepsen, Jens Richardt Mollegaard
AU - Nordentoft, Merete
AU - Thorup, Anne Amalie Elgaard
PY - 2022
Y1 - 2022
N2 - Objectives Childhood trauma increases the risk of developing mental illness as does being born to parents with schizophrenia or bipolar disorder. We aimed to compare prevalence of lifetime childhood trauma among 11-year-old children at familial high risk of schizophrenia (FHR-SZ) or bipolar disorder (FHR-BP) compared with population-based controls (PBCs). Design The study is a longitudinal, prospective cohort study of children at FHR-SZ, FHR-BP, and PBCs. Methods A cohort of 512 children at FHR-SZ (N = 199), FHR-BP (N = 118), and PBCs (N = 195) were examined at baseline (mean age 7.8, SD 0.2) and 451 children at FHR-SZ (N = 172), FHR-BP (N = 104), and PBCs (N = 175) were examined at four-year follow-up (mean age 11.9, SD 0.2, retention rate 87.3%). Childhood trauma was measured with a semi-structured interview. Results Children at FHR-BP had an elevated risk of exposure to any lifetime trauma (age 0-11 years) compared with PBCs (OR 2.082, 95%CI 1.223-3.545, p = .007) measured with binary logistic regression. One-way ANOVA revealed that both FHR-groups had a higher lifetime prevalence of exposure to a greater number of types of trauma compared with PBCs (FHR-SZ: observed mean: 1.53, 95%CI 1.29-1.77; FHR-BP: observed mean: 1.56, 95%CI 1.26-1.85; PBCs: observed mean: 0.99, 95%CI 0.82-1.17; p < .001). Binary logistic regression showed that the lifetime risk of exposure to interpersonal trauma (age 0-11 years) was elevated for both FHR-groups (FHR-SZ: OR 3.773, 95%CI 2.122-6.710, p < .001; FHR-BP: OR 3.602, 95%CI 1.913-6.783, p < .001). Conclusions Children at FHR-SZ and FHR-BP are at increased risk for being exposed to childhood trauma compared with PBCs. This study underscores the need for early detection, support, and prevention of childhood trauma in children at FHR-SZ and FHR-BP.
AB - Objectives Childhood trauma increases the risk of developing mental illness as does being born to parents with schizophrenia or bipolar disorder. We aimed to compare prevalence of lifetime childhood trauma among 11-year-old children at familial high risk of schizophrenia (FHR-SZ) or bipolar disorder (FHR-BP) compared with population-based controls (PBCs). Design The study is a longitudinal, prospective cohort study of children at FHR-SZ, FHR-BP, and PBCs. Methods A cohort of 512 children at FHR-SZ (N = 199), FHR-BP (N = 118), and PBCs (N = 195) were examined at baseline (mean age 7.8, SD 0.2) and 451 children at FHR-SZ (N = 172), FHR-BP (N = 104), and PBCs (N = 175) were examined at four-year follow-up (mean age 11.9, SD 0.2, retention rate 87.3%). Childhood trauma was measured with a semi-structured interview. Results Children at FHR-BP had an elevated risk of exposure to any lifetime trauma (age 0-11 years) compared with PBCs (OR 2.082, 95%CI 1.223-3.545, p = .007) measured with binary logistic regression. One-way ANOVA revealed that both FHR-groups had a higher lifetime prevalence of exposure to a greater number of types of trauma compared with PBCs (FHR-SZ: observed mean: 1.53, 95%CI 1.29-1.77; FHR-BP: observed mean: 1.56, 95%CI 1.26-1.85; PBCs: observed mean: 0.99, 95%CI 0.82-1.17; p < .001). Binary logistic regression showed that the lifetime risk of exposure to interpersonal trauma (age 0-11 years) was elevated for both FHR-groups (FHR-SZ: OR 3.773, 95%CI 2.122-6.710, p < .001; FHR-BP: OR 3.602, 95%CI 1.913-6.783, p < .001). Conclusions Children at FHR-SZ and FHR-BP are at increased risk for being exposed to childhood trauma compared with PBCs. This study underscores the need for early detection, support, and prevention of childhood trauma in children at FHR-SZ and FHR-BP.
KW - Childhood trauma
KW - familial high risk
KW - schizophrenia
KW - bipolar disorder
KW - follow-up
KW - PARENTAL PSYCHIATRIC-DISORDER
KW - PSYCHOTIC SYMPTOMS
KW - MENTAL-ILLNESS
KW - DIFFERENTIAL SUSCEPTIBILITY
KW - INTERPERSONAL TRAUMA
KW - DOMESTIC VIOLENCE
KW - PHYSICAL ABUSE
KW - SEXUAL ABUSE
KW - SPECTRUM
KW - STRESS
U2 - 10.1111/bjc.12364
DO - 10.1111/bjc.12364
M3 - Journal article
C2 - 35332530
VL - 61
SP - 875
EP - 894
JO - British Journal of Clinical Psychology
JF - British Journal of Clinical Psychology
SN - 0144-6657
IS - 4
ER -
ID: 303960244