Chest x-ray findings in tuberculosis patients identified by passive and active case finding: A retrospective study
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Chest x-ray findings in tuberculosis patients identified by passive and active case finding : A retrospective study. / Rastoder, Ema; Shaker, Saher Burhan; Naqibullah, Matiullah; Wille, Mathilde Marie Winkler; Lund, Mette; Wilcke, Jon Torgny; Seersholm, Niels; Jensen, Sidse Graff.
In: Journal of Clinical Tuberculosis and Other Mycobacterial Diseases, Vol. 14, 02.2019, p. 26-30.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Chest x-ray findings in tuberculosis patients identified by passive and active case finding
T2 - A retrospective study
AU - Rastoder, Ema
AU - Shaker, Saher Burhan
AU - Naqibullah, Matiullah
AU - Wille, Mathilde Marie Winkler
AU - Lund, Mette
AU - Wilcke, Jon Torgny
AU - Seersholm, Niels
AU - Jensen, Sidse Graff
PY - 2019/2
Y1 - 2019/2
N2 - Background: Chest x-ray is central in screening and diagnosis of tuberculosis. However, sputum culture remains gold standard for diagnosis. Aim: To establish the rate of normal chest x-rays in tuberculosis patients found by spot sputum culture screening, and compare them to a group identified through passive case finding. Method: Chest x-rays from 39 culture-positive patients, identified by spot sputum culture screening in Copenhagen from 2012 to 2014, were included in the study (spot sputum culture group(SSC)). 39 normal chest x-rays from persons screened by mobile x-ray, and 39 chest x-rays from tuberculosis-patients identified through passive case finding(PCF) were anonymised and randomised. Two respiratory physicians and two radiologists assessed the chest x-rays. Results: The normal chest x-ray rate was higher in the non-tuberculosis control group (median = 32 (82.1%), range = 74.4% – 100%), compared to the SSC group (median = 7 (17.9%), range = 10.3% – 33.3%), and the PCF controls (median = 3(7.7%), range = 2.6% – 15.4%). In the SSC group 14 (35.9%) were categorized as normal by at least one study participant. Conclusion: A substantial minority of patients diagnosed with tuberculosis by spot sputum culture screening, and through passive case finding would not have been identified with chest x-ray alone, highlighting that a normal chest x-ray does not exclude pulmonary tuberculosis.
AB - Background: Chest x-ray is central in screening and diagnosis of tuberculosis. However, sputum culture remains gold standard for diagnosis. Aim: To establish the rate of normal chest x-rays in tuberculosis patients found by spot sputum culture screening, and compare them to a group identified through passive case finding. Method: Chest x-rays from 39 culture-positive patients, identified by spot sputum culture screening in Copenhagen from 2012 to 2014, were included in the study (spot sputum culture group(SSC)). 39 normal chest x-rays from persons screened by mobile x-ray, and 39 chest x-rays from tuberculosis-patients identified through passive case finding(PCF) were anonymised and randomised. Two respiratory physicians and two radiologists assessed the chest x-rays. Results: The normal chest x-ray rate was higher in the non-tuberculosis control group (median = 32 (82.1%), range = 74.4% – 100%), compared to the SSC group (median = 7 (17.9%), range = 10.3% – 33.3%), and the PCF controls (median = 3(7.7%), range = 2.6% – 15.4%). In the SSC group 14 (35.9%) were categorized as normal by at least one study participant. Conclusion: A substantial minority of patients diagnosed with tuberculosis by spot sputum culture screening, and through passive case finding would not have been identified with chest x-ray alone, highlighting that a normal chest x-ray does not exclude pulmonary tuberculosis.
KW - Active case finding
KW - Chest x-ray assessment
KW - Chest x-ray changes
KW - Normal chest x-ray
KW - Passive case finding
KW - Tuberculosis
U2 - 10.1016/j.jctube.2019.01.003
DO - 10.1016/j.jctube.2019.01.003
M3 - Journal article
C2 - 31720415
AN - SCOPUS:85059785827
VL - 14
SP - 26
EP - 30
JO - Journal of Clinical Tuberculosis and Other Mycobacterial Diseases
JF - Journal of Clinical Tuberculosis and Other Mycobacterial Diseases
SN - 2405-5794
ER -
ID: 240194202